Polymorphisms of MMP-2 Gene are Associated With Systolic Heart Failure Risk in Han Chinese

被引:15
作者
Hua, Yihong [3 ]
Song, Li [4 ]
Wu, Naqiong [3 ]
Lu, Xiangfeng [1 ,2 ]
Meng, Xianmin [4 ]
Gu, Dongfeng [1 ,2 ]
Yang, Yuejin [3 ]
机构
[1] Fu Wai Hosp, Dept Evidence Based Med, Beijing, Peoples R China
[2] Fu Wai Hosp, Dept Populat Genet, Beijing, Peoples R China
[3] Fu Wai Hosp, Dept Cardiol, Beijing, Peoples R China
[4] Fu Wai Hosp, Cent Lab, Beijing, Peoples R China
关键词
MMP-2; Polymorphism; Systolic heart failure; Association study; CIRCULATING MATRIX METALLOPROTEINASE-2; HYPERTROPHIC CARDIOMYOPATHY; REPERFUSION INJURY; TISSUE INHIBITOR; IDENTICAL-TWINS; DYSFUNCTION; EXPRESSION; PROMOTER; MATRIX-METALLOPROTEINASE-9; VASOCONSTRICTOR;
D O I
10.1097/MAJ.0b013e31818eb2a2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes responsible for protein degradation. MMP-2 has been demonstrated to play a pivotal role in myocardial remodeling process that occurs in congestive heart failure (HF). We hypothesized that MMP-2 genetic variations could be associated with systolic HF risk. Methods: To test the association of single nucleotide polymorphisms of MMP-2 with systolic HF risk, we performed a hospital-based, case-control study of 605 patients with systolic HF and 689 controls without HE Three single nucleotide polymorphisms of MMP-2 (rs243864, rs243866, and rs17859821) were genotyped by restriction fragment length polymorphism methods. Results: The genotype frequencies of MMP-2 rs243866 AA and AG in the control group were significantly higher than that in the case group (24.7% versus 17.9%, P < 0.01). Compared with the GG homozygotes, MMP-2 rs243866 A allele carriers had a significantly lower risk of systolic HF (adjusted OR 0.69, 95% CI 0.49-0.98; P = 0.035). Haplotype analysis indicated the haplotype GGG (rs243864-rs17859821-rs243866) was associated with higher risk of systolic HF (adjusted OR 2.05. 95% CI 1.08-3.89; P = 0.028). Conclusion: The findings of the current study suggest that MMP-2 rs243866 A allele was associated with lower risk of systolic HF in Han Chinese.
引用
收藏
页码:344 / 348
页数:5
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