Lycium chinense leaves extract ameliorates diabetic nephropathy by suppressing hyperglycemia mediated renal oxidative stress and inflammation

被引：68
作者：
Olatunji, Opeyemi Joshua [1 ,2 ]
Chen, Hongxia [1 ]
Zhou, Yifeng [3 ,4 ]
机构：
[1] Jiangsu Univ, Sch Pharm, 301 Xuefu Rd, Zhenjiang 202013, Peoples R China
[2] Prince Songkla Univ, Fac Thai Tradit Med, Hat Yai 90112, Thailand
[3] Jiangsu Prov & Chinese Acad Sci, Nanjing Bot Garden, Inst Bot, Mem Sun Yat Sen, 1 Qianhuhoucun,POB 1435, Nanjing 210014, Jiangsu, Peoples R China
[4] Chinese Acad Sci, Nanjing Branch, Dongtai Inst Tidal Flat, Dongtai 224200, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2018年 / 102卷
关键词：
Lycium chinense; Diabetic nephropathy; Oxidative stress; Inflammation; GLYCATION END-PRODUCTS; HIGH GLUCOSE; MESANGIAL CELLS; KIDNEY-DISEASE; TYPE-2; PATHOGENESIS; ACTIVATION; PATHWAY; ACID; MILL;
D O I：
10.1016/j.biopha.2018.03.037
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Diabetic nephropathy is one of the most serious and most frequently encountered diabetic complication, accounting for the highest cause of end-stage renal disease. This present study was aimed at exploring the protective/attenuative effect of Lycium chinense leaf extract (MELC) on streptozotocin induced diabetic nephropathy in experimental Sprague Dawley rats. The oral administration of diabetic rats with MELC markedly ameliorated renal dysfunction as observed in the significant reduction in the serum levels of creatinine, blood urea nitrogen (BUN), albumin and TGF-beta 1 as compared to the untreated diabetic control rats. In addition, the elevated levels of renal oxidative stress markers and pro-inflammatory parameters (GSH, SOD, CAT, MDA, TNF-alpha, IL-6 and IL-1 beta) were significantly reduced in MELC treated diabetic rats. The results obtained in this study suggests that L. chinense leaf might have the potential as possible pharmacological agent against diabetic nephropathy by suppressing renal oxidative stress and inflammation.
引用
收藏
页码：1145 / 1151
页数：7
相关论文
共 57 条
[21]   The risk of developing end-stage renal disease in patients with type 2 diabetes and nephropathy: The RENAAL Study [J].
Keane, WF ;
Brenner, BM ;
de Zeeuw, D ;
Grunfeld, JP ;
McGill, J ;
Mitch, WE ;
Ribeiro, AB ;
Shahinfar, S ;
Simpson, RL ;
Snapinn, SM ;
Toto, R .
KIDNEY INTERNATIONAL, 2003, 63 (04) :1499-1507
[22]   Taste and flavor compounds in box thorn (Lycium chinense Miller) leaves [J].
Kim, SY ;
Lee, KH ;
Chang, KS ;
Bock, JY ;
Jung, MY .
FOOD CHEMISTRY, 1997, 58 (04) :297-303
[23]   The evolving role of natural products in drug discovery [J].
Koehn, FE ;
Carter, GT .
NATURE REVIEWS DRUG DISCOVERY, 2005, 4 (03) :206-220
[24]   Inflammation in Diabetic Nephropathy [J].
Lim, Andy K. H. ;
Tesch, Gregory H. .
MEDIATORS OF INFLAMMATION, 2012, 2012
[25]   NF-κB activation and overexpression of regulated genes in human diabetic nephropathy [J].
Mezzano, S ;
Aros, C ;
Droguett, A ;
Burgos, ME ;
Ardiles, L ;
Flores, C ;
Schneider, H ;
Ruiz-Ortega, M ;
Egido, J .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2004, 19 (10) :2505-2512
[26]   High glucose evokes an intrinsic proapoptotic signaling pathway in mesangial cells [J].
Mishra, R ;
Emancipator, SN ;
Kern, T ;
Simonson, MS .
KIDNEY INTERNATIONAL, 2005, 67 (01) :82-93
[27]  
Mizobuchi K. I., 1964, ANN REP FAC PHARM TO, V18, P27
[28]   Polyphenolic Content, Antioxidant and Antimicrobial Activities of Lycium barbarum L. and Lycium chinense Mill. Leaves [J].
Mocan, Andrei ;
Vlase, Laurian ;
Vodnar, Dan Cristian ;
Bischin, Cristina ;
Hanganu, Daniela ;
Gheldiu, Ana-Maria ;
Oprean, Radu ;
Silaghi-Dumitrescu, Radu ;
Crisan, Gianina .
MOLECULES, 2014, 19 (07) :10056-10073
[29]   Inflammation and diabetic nephropathy [J].
Mora C. ;
Navarro J.F. .
Current Diabetes Reports, 2006, 6 (6) :463-468
[30]   Elevated levels of interleukin-18 and tumor necrosis factor-α in serum of patients with type 2 diabetes mellitus:: Relationship with diabetic nephropathy [J].
Moriwaki, Y ;
Yamamoto, T ;
Shibutani, Y ;
Aoki, E ;
Tsutsumi, Z ;
Takahashi, S ;
Okamura, H ;
Koga, M ;
Fukuchi, M ;
Hada, T .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2003, 52 (05) :605-608
123456