Baseline ophthalmic findings in the vitamin E, cataract and age-related maculopathy (VECAT) study

Purpose: To describe the methodology of eye examination and the baseline eye characteristics or the Vitamin E, Cataract and Age-Related Maculopathy (VECAT) study participants Methods: A sample of volunteers from an urban area of Melbourne, Australia, were recruited to participate in a randomized, controlled trial investigating the effect of vitamin E on the development of cataract and age-related maculopathy. Standardized eye examinations involved clinical assessment, which included Wilmer grading of the lens, digital photography or the lens with Nidek EAS-1000 lens camera and stereo photography of the macular area with the Nidek 3-DX fundus camera. All cases of ophthalmic findings were determined on the basis of pathology in the worse eye. Results: Most eyes were free from abnormalities. The most frequent findings were cataract and age-related macular changes. Nuclear cataract (nuclear opacity grade greater than or equal to 2) was present in 4.5%, cortical cataract (cortical opacity grade greater than or equal to 2) in 14.3% and posterior subcapsular cataract in 3.0% of participants: in addition, coronary cataract was observed in 13.6%. Soft drusen larger than 125 mu m were round in 11.4%, retinal pigment epithelium changes in 9.5%, epiretinal membrane in 6.6% and age-related macular degeneration in 0.5% of participants. Summary: Due to the selection criteria, the majority of participants had clear or minor lens changes and/or minor retinal age-related changes. Precise instrumental documentation will allow an accurate assessment of the incidence and dynamics of these changes throughout 4 years of observation.