Effects of turmeric extract on lipid profile in human subjects

We investigated the unique cholesterol lowering property of turmeric (Curcuma longa). Total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) was measured in 33 subjects before and 15, 30 and 60 days after turmeric extract treatment (1 g turmeric extract twice a day). In all the subjects, total cholesterol (9.6-12.5%), triglyceride (16.2-34.3%) and LDL-C cholesterol (3.5-17%) declined significantly within 15 days. However, a minimal, though not significant, increase, occurred in HDL-cholesterol (5.5-8.5%). Although there was a 11.8% reduction in total cholesterol in normal subjects, the levels were within the normal range (3.6-9.2%). A similar trend occurred in triglycerides levels. Furthermore, this hypolipaemic effect of turmeric extract was accompanied by decreased plasma lipid peroxidation. The antioxidant property and use of turmeric are discussed for the prevention of coronary heart disease.