Characterising spatial heterogeneity of multiple myeloma in high resolution by whole body magnetic resonance imaging: Towards macro-phenotype driven patient management

被引：20

作者：

Latifoltojar, Arash ^{[1
]}

Boyd, Kevin ^{[1
]}

Riddell, Angela ^{[1
]}

Kaiser, Martin ^{[1
,2
]}

Messiou, Christina ^{[1
,2
]}

机构：

[1] Royal Marsden Hosp, Downs Rd, Sutton SM2 5PT, Surrey, England

[2] Inst Canc Res, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England

来源：

MAGNETIC RESONANCE IMAGING | 2021年 / 75卷

关键词：

Magnetic resonance imaging; Multiple myeloma; DISEASE; MRI; CRITERIA;

D O I：

10.1016/j.mri.2020.10.005

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Diagnosis of patients suspected of multiple myeloma requires a combination of serological and biochemical tests, bone marrow aspirate (BMA) and/or bone marrow trephine (BMT) biopsies as well as complementary information provided by whole-body cross-sectional imaging studies. However, given the heterogeneous nature of multiple myeloma, discrepancies can arise between disease burden on trephine and extent of disease within the marrow on whole-body magnetic resonance imaging (WB-MRI). Here, for the first time, we report on a series of symptomatic multiple myeloma patients for whom there was substantial discordance between disease burden on trephine and WB-MRI.

引用

页码：60 / 64

页数：5

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