DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPLC AND UV METHOD FOR PROTEASE INHIBITOR: A REVIEW

被引：0
作者：
Patil, Akshay B. [1 ]
Gurumukhi, Vishal C. [1 ]
Chalikwar, Shailesh S. [1 ]
Chaudhari, Dhanshri A. [1 ]
机构：
[1] RC Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut Qual Assurance, Shirpur, India
来源：
INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2019年 / 6卷 / 04期
关键词：
RP-HPLC; UV-spectrophotometry; Validation; Stability indicating; PERFORMANCE LIQUID-CHROMATOGRAPHY; HUMAN PLASMA; QUANTITATIVE-DETERMINATION; ANTIRETROVIRAL AGENTS; NELFINAVIR MESYLATE; ATAZANAVIR; RITONAVIR; INDINAVIR; SAQUINAVIR; DRUG;
D O I：
10.5281/zenodo.2652047
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A technique for the analysis of various duds using RP-HPLC and UV is an essential tool in chromatography. The HPLC method is able to separate, detect and selectively quantify the various drugs. After the method development using HPLC validation is done for the performance and reproducibility and repeatability and accuracy. Also, it will help to find out the limitations of the method and influence of factors to quantify the drug. Further, according to ICH guidelines, the established method processed with stability indicating evaluation to find out the robustness of the method. It includes forced degradation with acidic, basic, neutral condition, oxidation, photolytic degradation also done. In this review, we presented a protease inhibitor class drug and its quantification using HPLC and UV.
引用
收藏
页码：8381 / 8400
页数：20
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