Purified malaria pigment (hemozoin) enhances dendritic cell maturation and modulates the Isotype of antibodies induced by a DNA vaccine

被引：58

作者：

Coban, C

Ishii, KJ

Sullivan, DJ

Kumar, N ^{[1
]}

机构：

[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Malaria Res Inst, Baltimore, MD 21205 USA

[2] US FDA, Ctr Biol Evaluat & Res, Div Viral Prod, Bethesda, MD USA

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 07期

关键词：

D O I：

10.1128/IAI.70.7.3939-3943.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hemozoin (malaria pigment) has been implicated in the modulation of immune responses during malaria infection. This study was designed to evaluate the effect of purified hemozoin on the in vitro activation of myeloid dendritic cells. Our study also revealed that in addition to enhancing the maturation of dendritic cells, hemozoin also greatly promotes immunoglobulin G2a antibody responses when coadministered with a DNA vaccine plasmid encoding Pfs25, a Plasinodium falciparum transmission-blocking antigen.

引用

页码：3939 / 3943

页数：5

共 27 条

[1]

Arese P, 1997, ANN TROP MED PARASIT, V91, P501, DOI 10.1080/00034989760879

[2] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[3] Haemoproteus and Schistosoma synthesize heme polymers similar to Plasmodium hemozoin and β-hematin [J].

Chen, MM ;

Shi, LR ;

Sullivan, DJ .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2001, 113 (01) :1-8

[4] QUINOLINE ANTIMALARIAL-DRUGS INHIBIT SPONTANEOUS FORMATION OF BETA-HEMATIN (MALARIA PIGMENT) [J].

EGAN, TJ ;

ROSS, DC ;

ADAMS, PA .

FEBS LETTERS, 1994, 352 (01) :54-57

[5]

Lanzavecchia A, 1999, Haematologica, V84 Suppl EHA-4, P23

[6] Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity [J].

Liu, YJ .

CELL, 2001, 106 (03) :259-262

[7]

Lobo CA, 1999, INFECT IMMUN, V67, P1688

[8] Low interleukin-12 activity in severe Plasmodium falciparum malaria [J].

Luty, AJF ;

Perkins, DJ ;

Lell, B ;

Schmidt-Ott, R ;

Lehman, LG ;

Luckner, D ;

Greve, B ;

Matousek, P ;

Herbich, K ;

Schmid, D ;

Weinberg, JB ;

Kremsner, PG .

INFECTION AND IMMUNITY, 2000, 68 (07) :3909-3915

[9] Dendritic cells: Specialized and regulated antigen processing machines [J].

Mellman, I ;

Steinman, RM .

CELL, 2001, 106 (03) :255-258

[10]

PHU NH, 1995, T ROY SOC TROP MED H, V89, P200, DOI 10.1016/0035-9203(95)90496-4

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