Total Syntheses of Isomeric Spiroacetal Marine Natural Products Attenols A and B

被引：7
|
作者：
Kumar, Vemula Praveen [1 ]
Kavitha, Nerella [1 ]
Chandrasekhar, Srivari [1 ]
机构：
[1] CSIR Indian Inst Chem Technol, Nat Prod Chem Div, Hyderabad 500007, Andhra Pradesh, India
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2013卷 / 28期
关键词：
Natural products; Spiro compounds; Total synthesis; Olefination; ASYMMETRIC HYDRATION; ESTER; ACID; ALCOHOLS; STRATEGY; ANALOGS;
D O I：
10.1002/ejoc.201300703
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The convergent total synthesis of two marine natural products, attenols A and B is achieved with excellent stereocontrol. The synthetic route is based on an enantio- and regioselective Sharpless dihydroxylation, palladium(0)-catalyzed reduction to form -hydroxy-1-enoates, stereoselective mCPBA-mediated epoxidation, and Julia-Kocienski olefination.
引用
收藏
页码：6325 / 6334
页数：10
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