Functional alpha 1-adrenergic receptors on leukocytes of patients with polyarticular juvenile rheumatoid arthritis

被引：112

作者：

Heijnen, CJ ^{[1
]}

vanderVoort, CR ^{[1
]}

Wulffraat, N ^{[1
]}

vanderNet, J ^{[1
]}

Kuis, W ^{[1
]}

Kavelaars, A ^{[1
]}

机构：

[1] UNIV HOSP CHILDREN & YOUTH HET WILHELMINA KINDERZ, DEPT PEDIAT PHYS THERAPY, NL-3501 CA UTRECHT, NETHERLANDS

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1996年 / 71卷 / 1-2期

关键词：

juvenile rheumatoid arthritis; autonomic nervous system; adrenergic receptors; interleukin-6;

D O I：

10.1016/S0165-5728(96)00125-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During the last decade it has been shown that the central nervous system can influence the immune system. In healthy individuals, catecholamines can inhibit the production of pro-inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) via interaction with beta 2-adrenergic receptors. in contrast, we show here that catecholamines can stimulate the production of the interleukin-6 (IL-6) in children with the chronic inflammatory disease polyarticular juvenile rheumatoid arthritis (JRA). The induction of IL-6 is mediated by triggering of alpha 1-adrenergic receptors on peripheral blood leucocytes of the patients with polyarticular JRA. Functional alpha 1-adrenergic receptors are absent on leukocytes of normal donors and on leukocytes of patients with the oligoarticular form of the disease.

引用

页码：223 / 226

页数：4