Primer on Precision Medicine for Complex Chronic Disorders

被引：27
作者：
Whitcomb, David C. [1 ]
机构：
[1] Univ Pittsburgh, Dept Med Cell Biol & Mol Physiol & Human Genet, Pittsburgh, PA 15260 USA
来源：
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY | 2019年 / 10卷
关键词：
CHRONIC-PANCREATITIS; CLASSIFICATION; CONSENSUS; RECURRENT; BASKET; TRIAL;
D O I：
10.14309/ctg.0000000000000067
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Precision medicine promises patients with complex disorders the right treatment for the right patient at the right dose at the right time with expectation of better health at a lower cost. The demand for precision medicine highlights the limitations of modern Western medicine. Modern Western medicine is a population-based, top-down approach that uses pathology to define disease. Precision medicine is a bottom-up approach that identifies predisease disorders using genetics, biomarkers, and modeling to prevent disease. This primer demonstrates the contrasting strengths and limitations of each paradigm and why precision medicine will eventually deliver on the promises.
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