Nanosuspensions in drug delivery

被引：1170
|
作者：
Rabinow, BE [1 ]
机构：
[1] Baxter Healthcare Corp, Strateg Tech Dev, Round Lake, IL 60073 USA
来源：
NATURE REVIEWS DRUG DISCOVERY | 2004年 / 3卷 / 09期
关键词：
D O I：
10.1038/nrd1494
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A surprisingly large proportion of new drug candidates emerging from drug discovery programmes are water insoluble, and therefore poorly bioavailable, leading to abandoned development efforts. These so-called 'brickdust' candidates can now be rescued by formulating them into crystalline nanosuspensions. In the process of overcoming issues involving solubility, additional pharmacokinetic benefits of the drugs so formulated have come to be appreciated. As such, insolubility issues of the past have provoked a paradigm change, which now offers novel solutions for innovative drugs of the future.
引用
收藏
页码：785 / 796
页数：12
相关论文
共 50 条
  • [1] Nanosuspensions in drug delivery
    Barrett E. Rabinow
    Nature Reviews Drug Discovery, 2004, 3 : 785 - 796
  • [2] Stability of nanosuspensions in drug delivery
    Wang, Yancai
    Zheng, Ying
    Zhang, Ling
    Wang, Qiwei
    Zhang, Dianrui
    JOURNAL OF CONTROLLED RELEASE, 2013, 172 (03) : 1126 - 1141
  • [3] Safety of nanosuspensions in drug delivery
    Wang, Lulu
    Du, Juan
    Zhou, Yuqi
    Wang, Yancai
    NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2017, 13 (02) : 455 - 469
  • [4] Nanosuspensions A versatile drug delivery platform
    Cavalli, Roberta
    Leone, Federica
    CHIMICA OGGI-CHEMISTRY TODAY, 2013, 31 (04) : 46 - 49
  • [5] Nanosuspensions: a promising drug delivery strategy
    Patravale, VB
    Date, AA
    Kulkarni, RM
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2004, 56 (07) : 827 - 840
  • [6] Emerging role of nanosuspensions in drug delivery systems
    Shery Jacob
    Anroop B. Nair
    Jigar Shah
    Biomaterials Research, 24
  • [7] The technology for improving stability of nanosuspensions in drug delivery
    Guan, Wenhao
    Ma, Yingying
    Ding, Shuaijie
    Liu, Yanchao
    Song, Zimin
    Liu, Xiang
    Tang, Lingling
    Wang, Yancai
    JOURNAL OF NANOPARTICLE RESEARCH, 2022, 24 (01)
  • [8] NANOSUSPENSIONS - A PROMISING NOVEL DRUG DELIVERY SYSTEM
    Kumar, R. Santosh
    Kulkarni, Mangesh Pradeep
    Burela, Anjali
    INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 5 (03): : 1478 - 1484
  • [9] The technology for improving stability of nanosuspensions in drug delivery
    Wenhao Guan
    Yingying Ma
    Shuaijie Ding
    Yanchao Liu
    Zimin Song
    Xiang Liu
    Lingling Tang
    Yancai Wang
    Journal of Nanoparticle Research, 2022, 24
  • [10] Emerging role of nanosuspensions in drug delivery systems
    Jacob, Shery
    Nair, Anroop B.
    Shah, Jigar
    BIOMATERIALS RESEARCH, 2020, 24 (01)
12345