Pharmacotherapy Pearls in Rheumatology for the Care of Older Adult Patients Focus on Oral Disease-Modifying Antirheumatic Drugs and the Newest Small Molecule Inhibitors

被引：11

作者：

Betancourt, Blas Y. ^{[1
]}

Biehl, Ann ^{[2
]}

Katz, James D. ^{[1
]}

Subedi, Ananta ^{[1
]}

机构：

[1] NIAMSD, NIH, Ctr Clin, Bethesda, MD 20814 USA

[2] US FDA, Div Pharmacovigilance, Off Surveillance & Epidemiol, Ctr Drug Evaluat & Res, 10001 New Hampshire Ave,Hillandale Bldg,4th Floor, Silver Spring, MD 20993 USA

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2018年 / 44卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Geriatrics; DMARDs; Rheumatology; Rheumatoid arthritis; Tofacitinib; Apremilast; SYSTEMIC-LUPUS-ERYTHEMATOSUS; FUNCTIONAL HEALTH LITERACY; PLACEBO-CONTROLLED TRIAL; SEVERE PLAQUE PSORIASIS; LOW-DOSE METHOTREXATE; AGE-RELATED-CHANGES; LONG-TERM SAFETY; HERPES-ZOSTER; PHASE-III; PHOSPHODIESTERASE-4; INHIBITOR;

D O I：

10.1016/j.rdc.2018.03.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Providing safe and effective pharmacotherapy to geriatric patients with rheumatology disorders is challenging. Multidisciplinary care involving rheumatologists, primary care physicians, and other specialties can optimize benefit and reduce adverse outcomes. Oral disease-modifying antirheumatic drugs, including methotrexate, hydroxychloroquine, sulfasalazine, and leflunomide, and the small molecule inhibitors tofacitinib and apremilast have distinctive monitoring requirements and specific adverse reaction profiles. This article provides clinically relevant pearls for use of these interventions in older patients.

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页码：371 / +

页数：22

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