New Furanone Derivatives and Alkaloids from the Co-Culture of Marine-Derived Fungi Aspergillus sclerotiorum and Penicillium citrinum

被引：40

作者：

Bao, Jie ^{[1
]}

Wang, Jie ^{[1
]}

Zhang, Xiao-Yong ^{[1
]}

Nong, Xu-Hua ^{[1
]}

Qi, Shu-Hua ^{[1
]}

机构：

[1] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2017年 / 14卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Aspergillus sclerotiorum; Furanone derivatives; Complexes of neoaspergillic acid; 1,2,4-Oxadiazin-6-one; Cytotoxic activities; BIOSYNTHESIS; PYRROLES; ACID;

D O I：

10.1002/cbdv.201600327

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six new compounds including two furanone derivatives sclerotiorumins A and B (1 and 2), one novel oxadiazin derivative sclerotiorumin C (3), one pyrrole derivative 1-(4-benzyl-1H-pyrrol-3-yl)ethanone (4), and two complexes of neoaspergillic acid aluminiumneohydroxyaspergillin (5) and ferrineohydroxyaspergillin (6) were isolated from the co-culture of marine-derived fungi Aspergillus sclerotiorum and Penicillium citrinum. Compound 3 was the first natural 1,2,4-oxadiazin-6-one. Compound 5 showed significant and selective cytotoxicity against human histiocytic lymphoma U937 cell line (IC50=4.2 mu m) and strong toxicity towards brine shrimp (LC50=6.1 mu m), and oppositely increased the growth and biofilm formation of Staphylococcus aureus.

引用

页数：8

共 25 条

[1] PYRROLE CHEMISTRY .6. SYNTHESES AND ELECTROPHILIC SUBSTITUTION REACTIONS OF SOME 3-SUBSTITUTED PYRROLES [J].