DNA-mediated coordinative assembly of upconversion hetero-nanostructures for targeted dual-modality imaging of cancer cells

被引：22

作者：

Xue, Wenting ^{[1
,2
,3
]}

Di, Zhenghan ^{[2
,3
,4
]}

Zhao, Ya ^{[2
,3
]}

Zhang, Aiping ^{[1
]}

Li, Lele ^{[2
,3
,4
]}

机构：

[1] Shanxi Med Univ, Coll Pharm, Taiyuan 030001, Shanxi, Peoples R China

[2] Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[3] Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China

[4] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2019年 / 30卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Bioimaging; Upconversion nanoparticles; Self-assembly; Quantum dots; Cancer targeting; NANOPARTICLES; NANOCRYSTALS; STRATEGY; DELIVERY;

D O I：

10.1016/j.cclet.2019.03.022

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

superstructures has enormous potential in material sciences and engineering. Despite the potential, controlled assembly of different kinds of NPs into spatially addressable hybrid configurations still remains a formidable challenge. Herein, we report a simple and universal strategy for DNA-mediated assembly of CdTe quantum dots (QDs) and lanthanide-doped upconversion nanoparticles (UCNPs). Such DNA-QD/UCNPs heterostructures not only maintains both fluorescent properties of QDs and upconversion luminescence behaviors of UCNPs, but also offers a polyvalent DNA surface, allowing for targeted dual-modality imaging of cancer cells using an aptamer. The hetero-assembly mediated by the DNA - inorganic interfacial interaction may provide a scalable way to fabricate hybrid superstructures of both theoretical and practical interests. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：899 / 902

页数：4

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