Saliva NMR-Based Metabolomics in the War Against COVID-19

被引:23
作者
dos Santos Junior, Gilson Costa [4 ]
Pereira, Claudia Maria [1 ]
da Silva Fidalgo, Tatiana Kelly [2 ]
Valente, Ana Paula [3 ]
机构
[1] Grande Rio Univ, Postgrad Program Translat Biomed, BR-25071202 Duque De Caxias, RJ, Brazil
[2] Univ Estado Rio De Janeiro, Dent Sch, Dept Prevent & Community Dent, BR-20551030 Rio De Janeiro, Brazil
[3] Univ Fed Rio de Janeiro, Dept Struct Biol, BioNMR, CENABIO I, BR-21941599 Rio De Janeiro, Brazil
[4] Univ Estado Rio De Janeiro, Dept Genet, Lab NMR Metabol, IBRAG, BR-20551030 Rio De Janeiro, Brazil
关键词
TASTE SENSITIVITY; VIRUS-INFECTION; METABOLISM; PHENOTYPE; UNVEILS; PLASMA; DRUGS; ACID; H-1;
D O I
10.1021/acs.analchem.0c04679
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
COVID-19 is an emergent, worldwide public health concern. Joint efforts have been made by scientific communities of various fields to better understand the mechanisms of action of SARS-CoV-2. The need to understand the pathophysiological fingerprint and pathways of this disease make metabolomics-related approaches an indispensable tool for properly answering concerns relating to disease course. Determination of the metabolomic profile may help to explain the heterogeneous spectra of COVID-19 clinical phenotypes and be useful in monitoring disease progression as well as therapeutic treatments. In this sense, saliva has proven to be a strategic biofluid, owing not only to its appeal as a noninvasive sampling method but also due to the capacity of the virus to invade epithelial cells of the oral mucosa and salivary gland ducts via ACE2 receptors. Accordingly, important changes in metabolism have been described relating to COVID-19, indicating that metabolomics may open new avenues for understanding the pathophysiology of this disease, especially via longitudinal study designs. Thus, we discuss the importance of comprehending the SARS-CoV-2 salivary metabolomic fingerprint and also highlight the situation of Brazil on the frontlines of the war against COVID-19.
引用
收藏
页码:15688 / 15692
页数:5
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