New pyrone and cyclopentenone derivatives from marine-derived fungus Aspergillus sydowii SCSIO 00305

被引：19

作者：

Amin, Muhammad ^{[1
,2
]}

Liang, Xiao ^{[1
,2
]}

Ma, Xuan ^{[1
]}

Dong, Jun-De ^{[1
]}

Qi, Shu-Hua ^{[1
]}

机构：

[1] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Inst South China Sea Ecol & Environm Engn, Guangdong Key Lab Marine Mat Med,South China Sea, Guangzhou, Guangdong, Peoples R China

[2] Univ Chinese Acad Sci, Beijing, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 02期

关键词：

Aspergillus sydowii; 2-pyrone derivative; cyclopentenone derivative; mycotoxin; toxicity; DIPHENYL ETHERS; METABOLITES;

D O I：

10.1080/14786419.2019.1629919

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new 2-pyrone derivatives sydowiones A-B (1, 2), one new cyclopentenone derivative sydowione C (3), and one new mycotoxin 6-methoxyl austocystin A (4) along with two known analogues paecilpyrone A (5) and austocystin A (6), were isolated from the marine-derived fungus Aspergillus sydowii SCSIO 00305. The structures of 1-4 were elucidated by extensive spectroscopic analysis. The absolute configuration of C-8 in 1 was established by Mosher method, and further confirmed by calculation of the electronic circular dichroism (ECD) spectra. The absolute configuration of C-11 in 3 was also determined by calculation of ECD spectra. The absolute configuration of 6 was determined by a single-crystal X-ray diffraction experiment for the first time. Compounds 1-4 showed moderate toxicity towards brine shrine naupalii with LC50 values of 19.5, 14.3, 8.3 and 2.9 mu M, respectively. And 1 and 2 also showed antioxidant activity against 2,2-diphenyl-picrylhydrazyl (DPPH) radicals with IC50 values of 46.0 and 46.6 mu M, respectively. [GRAPHICS] .

引用

页码：318 / 326

页数：9

共 22 条

[1] Cyclopentenosine, major trifunctional crosslinking amino acid isolated from acid hydrolysate of elastin [J].