Paraoxonase 3 promotes cell proliferation and metastasis by PI3K/Akt in oral squamous cell carcinoma

被引：18
作者：
Zhu, Lili [1 ]
Shen, Yiyin [1 ]
Sun, Wei [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Stomatol, Shanghai, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2017年 / 85卷
关键词：
PON3; OSCC; Cell proliferation; AP-1; IMMUNE ESCAPE; CANCER; PATHWAY;
D O I：
10.1016/j.biopha.2016.11.084
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Paraoxonase 3 (PON3) is an oncogene in cancer, however, little is known about the mechanisms and roles of PON3 in oral squamous cell carcinoma (OSCC), which is the aim of our study. We found that the expression of PON3 was up-regulated in OSCC samples and cell lines. PON3 was associated with accelerating cell proliferation, cell cycle, migration and invasion in OSCC cells. Further research showed that PON3 was regulated by PI3K/Akt pathway. We also found that AP-1 was an important transcriptional factor regulating PON3 expression in OSCC. The study elucidates that PI3K/Akt pathway up-regulated the expression of PON3 in OSCC by AP-1. (C) 2016 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：712 / 717
页数：6
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