Stability of DNA Origami Nanostructure under Diverse Chemical Environments

被引：93

作者：

Kim, Hyojeong ^{[1
]}

Surwade, Sumedh P. ^{[1
]}

Powell, Anna ^{[1
]}

O'Donnell, Christina ^{[1
]}

Liu, Haitao ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

CHEMISTRY OF MATERIALS | 2014年 / 26卷 / 18期

关键词：

ATOMIC LAYER DEPOSITION; MOLECULAR LITHOGRAPHY; DEOXYRIBONUCLEIC-ACID; THIN-FILMS; SHAPES; OZONE; PROTEIN; METALS; ARRAYS; METALLIZATION;

D O I：

10.1021/cm5019663

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We report the effect of chemical and physical treatments on the structural stability of DNA origami nanostructures. Our result shows that DNA nanostructure maintains its shape under harsh processing conditions, including thermal annealing up to 200 degrees C for 10 min, immersing in a wide range of organic solvents for up to 24 h, brief exposure to alkaline aqueous solutions, and 5 min exposure to UV/O-3. Our result suggests that the application window of DNA nanostructure is significantly wider than previously believed.

引用

页码：5265 / 5273

页数：9

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