Review of 18F-Fluciclovine PET for Detection of Recurrent Prostate Cancer

被引:46
作者
Gusman, Mariya [1 ]
Aminsharifi, Jamie A. [2 ]
Peacock, Justin G. [1 ]
Anderson, Shane B. [3 ]
Clemenshaw, Michael N. [1 ,4 ]
Banks, Kevin P. [1 ,4 ]
机构
[1] Brooke Army Med Ctr, Dept Radiol, 3551 Roger Brooke Dr, San Antonio, TX 78219 USA
[2] US Air Force Acad, Dept Radiol, 10th Med Grp, Colorado Springs, CO 80840 USA
[3] Mt Med Phys Specialists, Salt Lake City, UT USA
[4] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA
关键词
SALVAGE RADIOTHERAPY; ACID; ASCT2;
D O I
10.1148/rg.2019180139
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Fluorine 18 (F-18) fluciclovine (anti-1-amino-3-F-18-fluorocydobutane-1-carboxylic acid [FACBC]) is a radiolabeled amino acid analog that takes advantage of the amino acid transport upregulation in several types of cancer cells. FACBC is taken up to a greater extent in prostate cancer cells than in surrounding normal tissue, providing an opportunity for its use in cases of this common cancer. In 2016, the U.S. Food and Drug Administration found the accuracy of FACBC PET to be superior to that of other molecular imaging techniques and subsequently granted approval for its use in PET of recurrent prostate cancer. As FACBC is an F-18 radiotracer, an on-site cyclotron is not required for its production. This feature enables the widespread clinical availability of this agent and, in turn, an opportunity for improved patient care. The clinical pharmacology and imaging features of FACBC are reviewed, and the role of this agent in the imaging of recurrent prostate cancer, within the context of research that supports its effectiveness, is discussed. The administration of and image acquisition facilitated by using FACBC, as compared with F-18 fluorodeoxyglucose, which is more widely used, are described. In addition, the criteria for interpreting FACBC imaging findings are outlined, with emphasis on common causes of false-positive and false-negative findings. (C) RSNA, 2019
引用
收藏
页码:822 / 841
页数:20
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