Synthesis of clickable amphiphilic polysaccharides as nanoscopic assemblies

被引：7
|
作者：
Fu, Liye [1 ]
Li, Lingyao [1 ]
Wang, Jun [1 ]
Knickelbein, Kyle [2 ]
Zhang, Lin [2 ]
Milligan, Ian [1 ]
Xu, Yi [1 ]
O'Hara, Kylie [1 ]
Bitterman, Lindsay [1 ]
Du, Wenjun [1 ]
机构：
[1] Cent Michigan Univ, Dept Chem Sci Adv Mat, Mt Pleasant, MI 48858 USA
[2] Univ Pittsburgh, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15213 USA
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 84期
关键词：
RING-OPENING POLYMERIZATION; CHEMICAL-SYNTHESIS; BLOCK-COPOLYMERS; EFFICIENT SYNTHESIS; NANOPARTICLES; DELIVERY; DERIVATIVES; CHEMISTRY; POLYMERS; GLUCOSE;
D O I：
10.1039/c4cc06343k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The synthesis of clickable polysaccharides was achieved by using alkynylated 1,6-anhydro glucopyranose as a monomer and BF3 center dot OEt2 as an effective catalyst. Subsequent click conjugation with polyethylene glycol (PEG) afforded PEG-grafted polysaccharides in nearly quantitative efficiency.
引用
收藏
页码：12742 / 12745
页数：4
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