Solid-phase synthesis of quinazolin-4(3H)-ones with three-point diversity

被引：33

作者：

Kesarwani, AP ^{[1
]}

Srivastava, GK ^{[1
]}

Rastogi, SK ^{[1
]}

Kundu, B ^{[1
]}

机构：

[1] Cent Drug Res Inst, Div Med Chem, Lucknow 226001, Uttar Pradesh, India

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 32期

关键词：

D O I：

10.1016/S0040-4039(02)01140-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A versatile method for the solid-phase synthesis of differentially substituted quinazolin-4(3H)-ones has been developed using immobilized arylguanidines. The latter were obtained by treating the amino group of polymer-linked anthranilamide with isothiocyanates followed by coupling with secondary amines in the presence of DIC. Finally a cyclative cleavage strategy was applied to give the desired compounds in high yields and purities. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：5579 / 5581

页数：3

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