N-myristoylation of the catalytic subunit of cAMP-dependent protein kinase in the free-living nematode Caenorhabditis elegans

被引:9
作者
Aspbury, RA
Fisher, MJ
Rees, HH
Clegg, RA
机构
[1] HANNAH RES INST,AYR KA6 5HL,SCOTLAND
[2] UNIV LIVERPOOL,DEPT BIOCHEM,LIVERPOOL L69 3BX,MERSEYSIDE,ENGLAND
基金
英国生物技术与生命科学研究理事会;
关键词
protein kinase A; Caenorhabditis elegans; myristoylation;
D O I
10.1006/bbrc.1997.7165
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
N-Myristoylation of the catalytic subunit (C-subunit) of cAMP-dependent protein kinase is widespread in animal cells. Some invertebrates express non-myristoylated isoforms of C-subunit but these co-exist with at least one myristoylated isoform. The generality of this observation implies an indispensable function for myristoylated C-subunit, but notwithstanding this, neither of the C-subunit isoforms hitherto described in C. elegans is apparently N-myristoylated. In light of this anomaly, the myristoylation status of the C-subunit has been examined in adult C. elegans. Evidence is presented for the presence of an N-myristoylated isoform. (C) 1997 Academic Press.
引用
收藏
页码:523 / 527
页数:5
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