The Role, Involvement and Function(s) of Interleukin-35 and Interleukin-37 in Disease Pathogenesis

被引：39

作者：

Bello, Ramatu Omenesa ^{[1
]}

Chin, Voon Kin ^{[2
,3
]}

Isnadi, Mohammad Faruq Abd Rachman ^{[1
]}

Majid, Roslaini Abd ^{[2
]}

Abdullah, Maizaton Atmadini ^{[4
]}

Lee, Tze Yan ^{[4
,5
]}

Zakaria, Zainul Amiruddin ^{[6
]}

Hussain, Mohd Khairi ^{[6
]}

Basir, Rusliza ^{[1
]}

机构：

[1] Univ Putra Malaysia, Dept Human Anat, Fac Med & Hlth Sci, Serdang 43400, Selangor, Malaysia

[2] Univ Putra Malaysia, Dept Med Microbiol & Parasitol, Fac Med & Hlth Sci, Serdang 43400, Selangor, Malaysia

[3] Int Inst Management & Technol, Wisma TLT, 51 & 51A,Jalan Sultan Azlan Shah, Kuala Lumpur 51200, Malaysia

[4] Univ Putra Malaysia, Dept Pathol, Fac Med & Hlth Sci, Serdang 43400, Selangor, Malaysia

[5] Perdana Univ, Sch Fdn Studies, Serdang 43400, Selangor, Malaysia

[6] Univ Putra Malaysia, Dept Biomed Sci, Fac Med & Hlth Sci, Serdang 43400, Selangor, Malaysia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 04期

关键词：

cytokines; interleukin-35; interleukin-37; pathogenesis; REGULATORY T-CELLS; RHEUMATOID-ARTHRITIS; SERUM-LEVELS; IL-1; FAMILY; AUTOIMMUNE-DISEASE; SYSTEMIC-SCLEROSIS; INNATE IMMUNITY; CYTOKINE IL-35; B-CELLS; MICE;

D O I：

10.3390/ijms19041149

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The recently identified cytokines-interleukin (IL)-35 and interleukin (IL)-37-have been described for their anti-inflammatory and immune-modulating actions in numerous inflammatory diseases, auto-immune disorders, malignancies, infectious diseases and sepsis. Either cytokine has been reported to be reduced and in some cases elevated and consequently contributed towards disease pathogenesis. In view of the recent advances in utilizing cytokine profiles for the development of biological macromolecules, beneficial in the management of certain intractable immune-mediated disorders, these recently characterized cytokines (IL-35 and IL-37) offer potential as reasonable targets for the discovery of novel immune-modulating anti-inflammatory therapies. A detailed comprehension of their sophisticated regulatory mechanisms and patterns of expression may provide unique opportunities for clinical application as highly selective and target specific therapeutic agents. This review seeks to summarize the recent advancements in discerning the dynamics, mechanisms, immunoregulatory and anti-inflammatory actions of IL-35 and IL-37 as they relate to disease pathogenesis.

引用

页数：28

共 113 条

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