Is immune senescence reversible?

被引：28

作者：

Beverley, PCL ^{[1
]}

Grubeck-Loebenstein, B

机构：

[1] Edward Jenner Inst Vaccine Res, Compton RG20 7NN, Berks, England

[2] Austrian Acad Sci, Inst Biomed Res Aging, A-6020 Innsbruck, Austria

来源：

VACCINE | 2000年 / 18卷 / 16期

关键词：

cytokines; dendritic cells; DNA repair; dysregulation; repertoire; thymic function;

D O I：

10.1016/S0264-410X(99)00514-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Many genes have been shown to be involved in the decline in immune function of the elderly. However, normal numbers of myeloid and lymphoid colonies can be grown from elderly bone marrow under optimal conditions and some thymic function is preserved well into adult life. It may also be possible to reverse partially declining thymic function by IL-7 treatment. Peripheral B and T cells show evidence of dysregulation with production of large clones, changes in subset distribution and altered signalling and cytokine production, particularly decreased IL-2 production in the mouse. The identification of these defects may lead to relatively simple procedures to improve vaccination for the elderly. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1721 / 1724

页数：4

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