From inflammation to cancer

被引:210
作者
Korniluk, A. [1 ]
Koper, O. [1 ]
Kemona, H. [1 ]
Dymicka-Piekarska, V. [1 ]
机构
[1] Med Univ Bialystok, Dept Clin Lab Diagnost, Ul Waszyngtona 15A, PL-15276 Bialystok, Poland
关键词
Acute inflammation; Chronic inflammation; Cancer; Adhesion molecules; LEUKOCYTE; SITE; RECRUITMENT; NEUTROPHILS; SHACTER; KAMP;
D O I
10.1007/s11845-016-1464-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background The participation of inflammation in the progression of cancer for many years have been the subject of research. Methods In the 19th century, there was evidence that an acute inflammation may inhibit the development of cancer. However, chronic inflammation affects the progression of the disease. Results Today, it is known that inflammation and cancer use similar mechanisms of development such as severe cell proliferation or angiogenesis. It has been shown that prolonged presence of inflammatory cells and factors in the tumor microenvironment can accelerate its growth and inhibit apoptosis of transformed cells. Conclusion In this article we present a brief history of the discovery mechanisms and potential links between acute and chronic inflammation and cancer.
引用
收藏
页码:57 / 62
页数:6
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