Delayed presentation of congenital tibial pseudarthrosis and neurofibromatosis: a different union

被引:2
作者
Hatton, Maxim J. [1 ]
Ly, Tho [1 ]
Noor, Saqib [1 ]
Gollogly, James G. [1 ]
机构
[1] Childrens Surg Ctr, Kien Kleang Natl Rehabil Ctr, Phnom Penh, Cambodia
关键词
Cambodia; congenital pseudarthrosis of tibia; Ilizarov; neurofibromatosis; non-union; PSEUDARTHROSIS; MULTICENTER; NF1;
D O I
10.5372/1905-7415.0801.269
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background: A new case of congenital pseudarthrosis of the tibia (CPT) presents yearly to CSC, but treatment is prolonged, and not always successful. Objective: To study the outcomes of treatment, and to determine whether a relationship with neurofibromatosis (NF) was of significance. Methods: A review of the medical records at our centre revealed 11 cases of CPT, 5 of which were associated with neurofibromatosis. Results: Most patients had multiple operations for their case of CPT, which did finally lead to union in 6 out of 6 cases with no NF, but in only 1 case out of 5 when NE was present. Conclusion: Late presentation and severe deformity can be overcome, and union can be achieved, but NF has a deleterious effect on obtaining union.
引用
收藏
页码:111 / 118
页数:8
相关论文
共 15 条
  • [1] Preliminary experience with the combined use of recombinant bone morphogenetic protein and bisphosphonates in the treatment of congenital pseudarthrosis of the tibia
    Birke, Oliver
    Schindeler, Aaron
    Ramachandran, Manoj
    Cowell, Chris T.
    Munns, Craig F.
    Bellemore, Michael
    Little, David G.
    [J]. JOURNAL OF CHILDRENS ORTHOPAEDICS, 2010, 4 (06) : 507 - 517
  • [2] BOYD HB, 1982, CLIN ORTHOP RELAT R, P5
  • [3] Carney Brian T, 2002, Iowa Orthop J, V22, P57
  • [4] A regenerative approach for bone repair in congenital pseudarthrosis of the tibia associated or not associated with type 1 neurofibromatosis: correlation between laboratory findings and clinical outcome
    Granchi, Donatella
    Devescovi, Valentina
    Baglio, Serena Rubina
    Magnani, Marina
    Donzelli, Onofrio
    Baldini, Nicola
    [J]. CYTOTHERAPY, 2012, 14 (03) : 306 - 314
  • [5] Treatment approaches for congenital pseudarthrosis of tibia: Results of the EPOS Multicenter Study
    Grill, F
    Bollini, G
    Dungl, P
    Fixsen, J
    Hefti, F
    Ippolito, E
    Romanus, B
    Tudisco, C
    Wientroub, S
    [J]. JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B, 2000, 9 (02): : 75 - 89
  • [6] Is double inactivation of the Nf1 gene responsible for the development of congenital pseudarthrosis of the tibia associated with NF1?
    Lee, Sang Min
    Choi, In Ho
    Lee, Dong Yeon
    Lee, Hye Ran
    Park, Moon Seok
    Yoo, Won Joon
    Chung, Chin Youb
    Cho, Tae-Joon
    [J]. JOURNAL OF ORTHOPAEDIC RESEARCH, 2012, 30 (10) : 1535 - 1540
  • [7] Congenital pseudarthrosis of neurofibromatosis type 1: Impaired osteoblast differentiation and function and altered NF1 gene expression
    Leskela, Hannu-Ville
    Kuorilehto, Tommi
    Risteli, Juha
    Koivunen, Jussi
    Nissinen, Marja
    Peltonen, Sirkku
    Kinnunen, Pentti
    Messiaen, Ludwine
    Lehenkari, Petri
    Peltonen, Juha
    [J]. BONE, 2009, 44 (02) : 243 - 250
  • [8] MASSERMAN RL, 1974, CLIN ORTHOP RELAT R, P140
  • [9] CONGENITAL PSEUDARTHROSIS OF THE TIBIA
    MORRISSY, RT
    RISEBOROUGH, EJ
    HALL, JE
    [J]. JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 1981, 63 (03): : 367 - 375
  • [10] Morrissy RT, 1982, CLIN ORTHOP RELAT R, P16621