Synthesis, X-ray crystal structure and cytotoxicity studies of zinc(II) and cadmium(II) iodide complexes with antipyrine

被引：18

作者：

Rukk, Nataliya S. ^{[1
]}

Kuzmina, Lyudmila G. ^{[2
]}

Albov, Dmitry V. ^{[3
]}

Shamsiev, Ravshan S. ^{[1
]}

Mudretsova, Svetlana N. ^{[3
]}

Davydova, Galina A. ^{[4
]}

Retivov, Vasilii M. ^{[5
]}

Volkov, Pavel A. ^{[5
]}

Kravchenko, Valerij V. ^{[1
]}

Apryshko, Galina N. ^{[6
]}

Streletskii, Andrej N. ^{[7
]}

Skryabina, Alena Yu. ^{[1
]}

Mironova, Elena A. ^{[4
]}

Zamalyutin, Vyacheslav V. ^{[1
]}

机构：

[1] Lomonosov Moscow State Univ Fine Chem Technol MIT, Moscow 119571, Russia

[2] NS Kurnakov Inst Gen & Inorgan Chem, Moscow 119991, Russia

[3] MV Lomonosov Moscow State Univ MSU, Dept Chem, Moscow 119992, Russia

[4] Russian Acad Sci, Inst Theoret & Expt Biophys, Pushchino 142290, Moscow Region, Russia

[5] Fed State Unitary Enterprise, Moscow 107076, Russia

[6] NN Blokhin Russian Canc Res Ctr, Moscow 115478, Russia

[7] NN Semenov Inst Chem Phys RAS, Moscow 119991, Russia

来源：

POLYHEDRON | 2015年 / 102卷

关键词：

Zinc and cadmium complexes; Antipyrine; Cytotoxicity; Crystal structure; Density functional calculations; MOLECULAR-STRUCTURE;

D O I：

10.1016/j.poly.2015.09.011

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Molecular complex [Zn(AP)(2)I-2] (1) and the isomorphous ones [Cd(AP)(6)][Cd(AP)X-3](2) consisting of octahedral complex cations [Cd(AP)(6)](2+) and the respective complex anions [Cd(AP)X-3](-) (AP - antipyrine, 2,3-dithethyl-1-phenyl-3-pyrazolin-5-one; X = I (2) or Br(3)) were prepared and characterized by single crystal X-ray diffraction, IR vibrational spectroscopy, thermal analysis and DFT calculations. It was found that antipyrine molecules are coordinated by the metal atom, in both zinc-containing molecular complex (1) and in the cadmium-containing complex cations and anions (compounds (2) and (3)), via an oxygen atom of the ligand carbonyl group. The experimental results confirm the calculated ones. Both zinc (cadmium) iodides and their antipyrine complexes demonstrate cytotoxic activity in vitro at 10(-5)-10(-3) mol/L, and are promising ones for further investigations of their anticancer activity both in vitro and in vivo. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：152 / 162

页数：11

共 50 条

[21] Synthesis, characterization and X-ray crystal structure determination of platinum(II)-diaminoalkane complexes
Department of Chemistry, Queen's University, Kingston, Ont. K7L 3N6, Canada
Inorg. Chim. Acta, 1 (53-63):
[22] Synthesis and X-ray crystal structure of a macrocyclic binuclear cadmium(II) complex with side chain
Wang, J
Xu, XY
Chen, JL
Luo, QH
Shen, MC
Huang, XY
Wu, QJ
INORGANICA CHIMICA ACTA, 1997, 256 (01) : 121 - 124
[23] Synthesis and X-ray crystal structure of a macrocyclic binuclear cadmium(II) complex with side chain
Wang, J.
Xu, X.
Chen, J.
Luo, Q.
Inorganica Chimica Acta, 256 (01):
[24] 'Cobalt(II), Nickel(II) and Zinc(II) complexes based on DHA: Synthesis, X-ray crystal structure, antibacterial activity and DFT computational studies' (vol 1, 128353, 2020)
Marir, Amel
Mouas, Toma Nardjes
Anak, Barkahem
Jeanneau, Erwann
Djedouani, Amel
Zouioueche, Louisa Aribi
Rabilloud, Franck
JOURNAL OF MOLECULAR STRUCTURE, 2022, 1255
[25] Synthesis, X-ray crystal structure and biological evaluation of zinc(II)-dichlorido complexes with 9-deazahypoxathine derivatives
Galikova, Jana
Hosek, Jan
Travnicek, Zdenek
INORGANICA CHIMICA ACTA, 2015, 434 : 67 - 73
[26] ALKALINE-EARTH, LEAD(II), AND CADMIUM(II) COMPLEXES OF A NITROGEN ANALOG OF [18]ANNULENE - X-RAY CRYSTAL-STRUCTURE OF THE LEAD AND CADMIUM COMPLEXES
DREW, MGB
CABRAL, JDO
CABRAL, MF
ESHO, FS
NELSON, SM
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1979, (22) : 1033 - 1035
[27] Synthesis, X-ray crystal structure, DNA/protein binding, DNA cleavage and cytotoxicity studies of N(4) substituted thiosemicarbazone based copper(II)/nickel(II) complexes
Muralisankar, Mathiyan
Haribabu, Jebiti
Bhuvanesh, Nattamai S. P.
Karvembu, Ramasamy
Sreekanth, Anandaram
INORGANICA CHIMICA ACTA, 2016, 449 : 82 - 95
[28] Synthesis, characterization and X-ray crystal structures of the bis-ligand zinc(II) and cadmium(II) complexes of the methylpyruvate Schiff base of S-methyldithiocarbazate
Ali M.A.
Mirza A.H.
Fong G.A.
Transition Metal Chemistry, 2004, 29 (06) : 613 - 619
[29] Spectral and single crystal X-ray structural studies on disulfide complexes: reaction of bis(dialkyldithiocarbamato) M(II) with iodine and crystal structure determination of diiodo(bipiperidinethiuramdisulfide) M(II) (M = zinc, cadmium)
Thirumaran, S
Ramalingam, K
Bocelli, G
Cantoni, A
POLYHEDRON, 2000, 19 (10) : 1279 - 1282
[30] Synthesis, X-ray structure and molecular modelling analysis of cobalt(II), nickel(II), zinc(II) and cadmium(II) complexes of the widely used anti-inflammatory drug meloxicam
Defazio, S
Cini, R
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 2002, (09): : 1888 - 1897

← 1 2 3 4 5 →