Synthesis, X-ray crystal structure and cytotoxicity studies of zinc(II) and cadmium(II) iodide complexes with antipyrine

被引：18

作者：

Rukk, Nataliya S. ^{[1
]}

Kuzmina, Lyudmila G. ^{[2
]}

Albov, Dmitry V. ^{[3
]}

Shamsiev, Ravshan S. ^{[1
]}

Mudretsova, Svetlana N. ^{[3
]}

Davydova, Galina A. ^{[4
]}

Retivov, Vasilii M. ^{[5
]}

Volkov, Pavel A. ^{[5
]}

Kravchenko, Valerij V. ^{[1
]}

Apryshko, Galina N. ^{[6
]}

Streletskii, Andrej N. ^{[7
]}

Skryabina, Alena Yu. ^{[1
]}

Mironova, Elena A. ^{[4
]}

Zamalyutin, Vyacheslav V. ^{[1
]}

机构：

[1] Lomonosov Moscow State Univ Fine Chem Technol MIT, Moscow 119571, Russia

[2] NS Kurnakov Inst Gen & Inorgan Chem, Moscow 119991, Russia

[3] MV Lomonosov Moscow State Univ MSU, Dept Chem, Moscow 119992, Russia

[4] Russian Acad Sci, Inst Theoret & Expt Biophys, Pushchino 142290, Moscow Region, Russia

[5] Fed State Unitary Enterprise, Moscow 107076, Russia

[6] NN Blokhin Russian Canc Res Ctr, Moscow 115478, Russia

[7] NN Semenov Inst Chem Phys RAS, Moscow 119991, Russia

来源：

POLYHEDRON | 2015年 / 102卷

关键词：

Zinc and cadmium complexes; Antipyrine; Cytotoxicity; Crystal structure; Density functional calculations; MOLECULAR-STRUCTURE;

D O I：

10.1016/j.poly.2015.09.011

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Molecular complex [Zn(AP)(2)I-2] (1) and the isomorphous ones [Cd(AP)(6)][Cd(AP)X-3](2) consisting of octahedral complex cations [Cd(AP)(6)](2+) and the respective complex anions [Cd(AP)X-3](-) (AP - antipyrine, 2,3-dithethyl-1-phenyl-3-pyrazolin-5-one; X = I (2) or Br(3)) were prepared and characterized by single crystal X-ray diffraction, IR vibrational spectroscopy, thermal analysis and DFT calculations. It was found that antipyrine molecules are coordinated by the metal atom, in both zinc-containing molecular complex (1) and in the cadmium-containing complex cations and anions (compounds (2) and (3)), via an oxygen atom of the ligand carbonyl group. The experimental results confirm the calculated ones. Both zinc (cadmium) iodides and their antipyrine complexes demonstrate cytotoxic activity in vitro at 10(-5)-10(-3) mol/L, and are promising ones for further investigations of their anticancer activity both in vitro and in vivo. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：152 / 162

页数：11

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