Biliary atresia with hyperandrogenic amenorrhea: case report

被引：0
作者：
Hebiguchi, T [1 ]
Kato, T [1 ]
Yoshino, H [1 ]
Mizuno, M [1 ]
Takahashi, T [1 ]
Fukuda, J [1 ]
Tanaka, T [1 ]
机构：
[1] Akita Univ, Sch Med, Dept Pediat Surg, Akita 0108543, Japan
来源：
PEDIATRIC SURGERY INTERNATIONAL | 2000年 / 16卷 / 1-2期
关键词：
biliary atresia; hypertestosteronemic amenorrhea; liver cirrhosis; portosystemic shunt; metabolic clearance;
D O I：
10.1007/s003830050034
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The etiology of hyperandrogenic amenorrhea in a 16 year-old girl after a successful Kasai operation for biliary atresia was unclear. Delayed puberty and menarche were observed. There was no luteinizing hormone-follicular stimulating hormone surge. A provocative luteinizing hormone-releasing hormone test showed a normal response. Peripheral aromatization of androgens appeared to function normally. However, plasma levels of sex hormone-binding globulin and total testosterone were high and the free testosterone level was normal. The anovulatory menstrual cycle continued after menarche at 18 years of age. A combination of estrogen and progesterone therapy was effective. The etiology might be associated with delayed metabolic clearance of testosterone accompanied by the compensatory cirrhosis and portosystemic shunt.
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页码：113 / 115
页数：3
相关论文
共 9 条
  • [1] HIRSUTISM, ITS PATHOGENESIS[J]. BRECKWOLDT, M;ZAHRADNIK, HP;WIEACKER, P. HUMAN REPRODUCTION, 1989(06)
  • [2] RECOVERY OF MENSTRUATION AND PREGNANCY AFTER LIVER-TRANSPLANTATION[J]. CUNDY, TF;OGRADY, JG;WILLIAMS, R. GUT, 1990(03)
  • [3] BODY-FAT MASS, BODY-FAT DISTRIBUTION, AND PUBERTAL DEVELOPMENT - A LONGITUDINAL-STUDY OF PHYSICAL AND HORMONAL SEXUAL-MATURATION OF GIRLS[J]. DERIDDER, CM;THIJSSEN, JHH;BRUNING, PF;VANDENBRANDE, JL;ZONDERLAND, ML;ERICH, WBM. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1992(02)
  • [4] ESTROGEN AND ANDROGEN REGULATION OF SEX-HORMONE BINDING GLOBULIN SECRETION BY A HUMAN LIVER-CELL LINE[J]. EDMUNDS, SEJ;STUBBS, AP;SANTOS, AA;WILKINSON, ML. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1990(05)
  • [5] JOSEPH DR, 1994, VITAM HORM, V49, P197
  • [6] WIDESPREAD TISSUE DISTRIBUTION OF STEROID SULFATASE, 3-BETA-HYDROXYSTEROID DEHYDROGENASE DELTA(5)-DELTA(4) ISOMERASE (3-BETA-HSD), 17-BETA-HSD 5-ALPHA-REDUCTASE AND AROMATASE ACTIVITIES IN THE RHESUS-MONKEY[J]. MARTEL, C;MELNER, MH;GAGNE, D;SIMARD, J;LABRIE, F. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1994(01)
  • [7] DELAYED PUBERTY IN GIRLS HAVING BILIARY ATRESIA[J]. NAKANO, M;SAEKI, M;HAGANE, K. JOURNAL OF PEDIATRIC SURGERY, 1990(07)
  • [8] THE EFFECTS OF ANDROGENS AND CORTISOL ON THE INVIVO METABOLISM OF ESTRADIOL[J]. REED, MJ;LAI, LC;GHILCHIK, MW;JAMES, VHT. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1988(1-6)
  • [9] ROSENFIELD RL, 1990, PEDIATR CLIN N AM, V37, P1333
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