Inhibition of melanoma metastases by fenofibrate

被引：69
作者：
Grabacka, M
Placha, W
Plonka, PM
Pajak, S
Urbanska, K
Laidler, P
Slominski, A
机构：
[1] Temple Univ, Coll Sci & Technol, Ctr Neurovirol & Canc Biol, Philadelphia, PA 19122 USA
[2] Jagiellonian Univ, Collegium Medicum, Inst Biochem, PL-31034 Krakow, Poland
[3] Univ Tennessee, Ctr Hlth Sci, Dept Pathol & Lab Med, Memphis, TN 38163 USA
[4] Jagiellonian Univ, Fac Biotechnol, PL-30387 Krakow, Poland
来源：
ARCHIVES OF DERMATOLOGICAL RESEARCH | 2004年 / 296卷 / 02期
关键词：
chemoprevention; fenofibrate; metastases; PPAR; Syrian hamster; transplantable melanoma;
D O I：
10.1007/s00403-004-0479-y
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The effect of fenofibrate, a ligand of peroxisome proliferator-activated receptor (PPAR) alpha, on the growth and metastatic potential of Bomirski hamster melanoma s.c. tumors, pigmented line (BHM Ma) was investigated in vivo. RT-PCR and Western-blot analyses revealed the presence of mRNA and protein of PPAR alpha in BHM Ma cells. The animals treated orally with fenofibrate developed significantly fewer metastatic foci in the lungs, as compared to the control group; however, primary tumor growth remained unaltered. This observation is interesting in respect of the potential use of fenofibrate in melanoma chemoprevention.
引用
收藏
页码：54 / 58
页数：5
相关论文
共 54 条
  • [1] EFFECTS OF FIBRIC ACID-DERIVATIVES ON ACCUMULATION OF ACTIN IN MYOCARDIOCYTES
    ARANEGA, A
    GONZALEZ, FJ
    ARANEGA, AE
    MUROS, MA
    FERNANDEZ, JE
    VELEZ, C
    PRADOS, J
    ALVAREZ, L
    [J]. INTERNATIONAL JOURNAL OF CARDIOLOGY, 1991, 33 (01) : 47 - 54
  • [2] Aranega AE, 1995, EUR J MORPHOL, V33, P421
  • [3] REVIEW OF EUROPEAN CLINICAL-EXPERIENCE WITH FENOFIBRATE
    BLANE, GF
    [J]. CARDIOLOGY, 1989, 76 : 1 - 13
  • [4] THE NATURAL-HISTORY OF A FAMILY OF TRANSPLANTABLE MELANOMAS IN HAMSTERS
    BOMIRSKI, A
    SLOMINSKI, A
    BIGDA, J
    [J]. CANCER AND METASTASIS REVIEWS, 1988, 7 (02) : 95 - 118
  • [5] Cardones AR, 2003, CANCER RES, V63, P6751
  • [6] Chinetti G, 2001, Z Kardiol, V90 Suppl 3, P125
  • [7] CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2
  • [8] Dellavalle Robert P, 2003, Am J Ther, V10, P203, DOI 10.1097/00045391-200305000-00007
  • [9] Chemoprevention of melanoma: An unexplored strategy
    Demierre, MF
    Nathanson, L
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (01) : 158 - 165
  • [10] Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels - Results of AFCAPS/TexCAPS
    Downs, JR
    Clearfield, M
    Weis, S
    Whitney, E
    Shapiro, DR
    Beere, PA
    Langendorfer, A
    Stein, EA
    Kruyer, W
    Gotto, AM
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 279 (20): : 1615 - 1622
123456