Nanoholes As Nanochannels: Flow-through Plasmonic Sensing

被引：247
作者：
Eftekhari, Fatemeh [1 ]
Escobedo, Carlos [1 ]
Ferreira, Jacqueline [1 ,2 ]
Duan, Xiaobo [3 ]
Girotto, Emerson M. [2 ]
Brolo, Alexandre G. [1 ]
Gordon, Reuven [1 ]
Sinton, David [1 ]
机构：
[1] Univ Victoria, Victoria, BC, Canada
[2] Univ Estadual Maringa, Maringa, Parana, Brazil
[3] British Columbia Canc Agcy, Trev & Joyce Deeley Res Ctr, Victoria, BC, Canada
来源：
ANALYTICAL CHEMISTRY | 2009年 / 81卷 / 11期
基金：
加拿大自然科学与工程研究理事会;
关键词：
EXTRAORDINARY OPTICAL-TRANSMISSION; SELF-ASSEMBLED MONOLAYERS; REAL-TIME; ENHANCED TRANSMISSION; SURFACE; ARRAYS; RESONANCE; SPECTROSCOPY; KINETICS; BINDING;
D O I：
10.1021/ac900221y
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
We combine nanofluidics and nanoplasmonics for surface-plasmon resonance (SPR) sensing using flow-through nanohole arrays. The role of surface plasmons on resonant transmission motivates the application of nanohole arrays as surface-based biosensors. Research to date, however, has focused on dead-ended holes, and therefore failed to harness the benefits of nanoconfined transport combined with SPR sensing. The flow-through format enables rapid transport of reactants to the active surface inside the nanoholes, with potential for significantly improved time of analysis and biomarker yield through nanohole sieving. We apply the flow-through method to monitor the formation of a monolayer and the immobilization of an ovarian cancer biomarker specific antibody on the sensing surface in real-time. The flow-through method resulted in a 6-fold improvement in response time as compared to the established flow-over method.
引用
收藏
页码：4308 / 4311
页数：4
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