Reprogramming of Cellular Metabolism and Its Therapeutic Applications in Thyroid Cancer

被引：13

作者：

Nagayama, Yuji ^{[1
]}

Hamada, Koichiro ^{[1
,2
]}

机构：

[1] Nagasaki Univ, Atom Bomb Dis Inst, Dept Mol Med, 1-12-4 Sakamoto, Nagasaki 8528523, Japan

[2] Nagasaki Univ, Dept Gen Med, Grad Sch Biomed Sci, Nagasaki 8528501, Japan

来源：

METABOLITES | 2022年 / 12卷 / 12期

关键词：

thyroid cancer; metabolomics; the Warburg effect; glycolysis; TCA cycle; electron transport chain; lipid metabolism; glutaminolysis; BRAF V600E MUTATION; FATTY-ACID SYNTHASE; HURTHLE CELL; COMPLEX-I; GLUTAMINE-METABOLISM; MITOCHONDRIAL-DNA; TRANSPORTER EXPRESSION; GLUCOSE-METABOLISM; CARCINOMA; GLUCOSE-TRANSPORTER-1;

D O I：

10.3390/metabo12121214

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolism is a series of life-sustaining chemical reactions in organisms, providing energy required for cellular processes and building blocks for cellular constituents of proteins, lipids, carbohydrates and nucleic acids. Cancer cells frequently reprogram their metabolic behaviors to adapt their rapid proliferation and altered tumor microenvironments. Not only aerobic glycolysis (also termed the Warburg effect) but also altered mitochondrial metabolism, amino acid metabolism and lipid metabolism play important roles for cancer growth and aggressiveness. Thus, the mechanistic elucidation of these metabolic changes is invaluable for understanding the pathogenesis of cancers and developing novel metabolism-targeted therapies. In this review article, we first provide an overview of essential metabolic mechanisms, and then summarize the recent findings of metabolic reprogramming and the recent reports of metabolism-targeted therapies for thyroid cancer.

引用

页数：14

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