TB vaccines: current status and future perspectives

被引：62
|
作者：
Aagaard, Claus [1 ]
Dietrich, Jes [1 ]
Doherty, Mark [1 ]
Andersen, Peter [1 ]
机构：
[1] Statens Serum Inst, Dept Infect Dis Immunol, DK-2300 Copenhagen, Denmark
来源：
IMMUNOLOGY AND CELL BIOLOGY | 2009年 / 87卷 / 04期
关键词：
tuberculosis; bacterial; vaccination; BCG; latency; MYCOBACTERIUM-TUBERCULOSIS INFECTION; BACILLUS-CALMETTE-GUERIN; DELAYED-TYPE HYPERSENSITIVITY; BOVIS BCG VACCINE; INTERFERON-GAMMA; PROTECTIVE IMMUNITY; SUBUNIT VACCINE; LATENT TUBERCULOSIS; IN-VITRO; ENVIRONMENTAL MYCOBACTERIA;
D O I：
10.1038/icb.2009.14
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Vaccines against intracellular pathogens such as Mycobacterium tuberculosis need to induce strong cellular immune responses. Antigen discovery programs have exploited this and used proteome studies and T-cell recognition in PPD-positive individuals to select proteins and after testing for protective efficacy in animals the most promising proteins have been put together in fusion molecules. Three such fusion proteins are currently in clinical trials, the two most advanced have already passed phase I trials and are entering phase II. Immunology and Cell Biology ( 2009) 87, 279-286; doi:10.1038/icb.2009.14; published online 7 April 2009
引用
收藏
页码：279 / 286
页数：8
相关论文
共 50 条
  • [31] Controlled Release Technologies for Chronotherapy: Current Status and Future Perspectives
    Bhat, Bhavana B.
    Mehta, Chetan H.
    Suresh, Akhil
    Velagacherla, Varalakshmi
    Nayak, Usha Y.
    CURRENT PHARMACEUTICAL DESIGN, 2023, 29 (14) : 1069 - 1091
  • [32] Approaches on Ferrofluid Synthesis and Applications: Current Status and Future Perspectives
    Oehlsen, Oscar
    Cervantes-Ramirez, Sussy, I
    Cervantes-Aviles, Pabel
    Medina-Velo, Illya A.
    ACS OMEGA, 2022, 7 (04): : 3134 - 3150
  • [33] The virtual cell based assay: Current status and future perspectives
    Graepel, Rabea
    Lamon, Lara
    Asturiol, David
    Berggren, Elisabet
    Joossens, Elisabeth
    Paini, Alicia
    Prieto, Pilar
    Whelan, Maurice
    Worth, Andrew
    TOXICOLOGY IN VITRO, 2017, 45 : 258 - 267
  • [34] Boron neutron capture therapy: Current status and future perspectives
    Dymova, Mayya Alexandrovna
    Taskaev, Sergey Yurjevich
    Richter, Vladimir Alexandrovich
    Kuligina, Elena Vladimirovna
    CANCER COMMUNICATIONS, 2020, 40 (09) : 406 - 421
  • [35] Current status and future perspectives of immunotherapy in bladder cancer treatment
    Wu, Zhangsong
    Liu, Jinjian
    Dai, Ruixiang
    Wu, Song
    SCIENCE CHINA-LIFE SCIENCES, 2021, 64 (04) : 512 - 533
  • [36] Immunomodulation as a Therapy for Aspergillus Infection: Current Status and Future Perspectives
    Lauruschkat, Chris D.
    Einsele, Hermann
    Loeffler, Juergen
    JOURNAL OF FUNGI, 2018, 4 (04)
  • [37] Proteomics in Biomarker Discovery for Tuberculosis: Current Status and Future Perspectives
    Guo, Jiubiao
    Zhang, Ximeng
    Chen, Xinchun
    Cai, Yi
    FRONTIERS IN MICROBIOLOGY, 2022, 13
  • [38] Buckwheat in Tissue Culture Research: Current Status and Future Perspectives
    Tomasiak, Alicja
    Zhou, Meiliang
    Betekhtin, Alexander
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (04)
  • [39] Apigenin as an emerging hepatoprotective agent: current status and future perspectives
    Wang, Cheng
    Feng, Xiaoli
    Li, Wen
    Chen, Li
    Wang, Xinming
    Lan, Yimiao
    Tang, Rong
    Jiang, Ting
    Zheng, Lingli
    Liu, Gang
    FRONTIERS IN PHARMACOLOGY, 2024, 15
  • [40] Regulatory science for hernia mesh: Current status and future perspectives
    Liu, Wenbo
    Xie, Yajie
    Zheng, Yudong
    He, Wei
    Qiao, Kun
    Meng, Haoye
    BIOACTIVE MATERIALS, 2021, 6 (02) : 420 - 432
12345