Serum levels of albumin-amyloid beta complexes are decreased in Alzheimer's disease

被引：41

作者：

Yamamoto, Keiichi ^{[1
]}

Shimada, Hiroyuki ^{[1
]}

Koh, Hideo ^{[2
]}

Ataka, Suzuka ^{[1
]}

Miki, Takami ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Med, Dept Geriatr Med & Neurol, Osaka 5458585, Japan

[2] Osaka City Univ, Grad Sch Med, Dept Hematol, Osaka 5458585, Japan

来源：

GERIATRICS & GERONTOLOGY INTERNATIONAL | 2014年 / 14卷 / 03期

关键词：

albumin; Alzheimer's disease; amyloid; biomarkers; serum; CSF BIOMARKERS; MOUSE MODEL; PLASMA; CLEARANCE; PROTEIN; BURDEN; BRAIN; IGG; CNS;

D O I：

10.1111/ggi.12147

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

AimDecreased amyloid (A) clearance from the brain to blood might play a key role in the development of Alzheimer's disease (AD). A is normally bound to and transported by albumin in blood, thus possibly maintaining constant concentration of free A in the blood. We therefore hypothesized that decreased blood levels of albumin-A complexes could be associated with decreased A removal from the brain to blood, resulting in A accumulation in the brain. MethodsWe carried out a cross-sectional investigation of the association between serum levels of albumin-A complexes (SLAAC) and AD prevalence in 89 patients who visited our outpatient clinic, and gave written informed consent between August 2008 and May 2012. ResultsWe confirmed 45 cases of AD. Low SLAAC was associated with an increased prevalence of AD (OR 0.27; 95% CI 0.14-0.51) in a univariable logistic model and multivariable logistic models. In addition, decreased SLAAC was associated with decreased levels of A42 in CSF (r=0.38, P=0.0221) and increased levels of p-tau in CSF (r=-0.43, P=0.0090), findings that have been shown to be associated with AD progression. ConclusionsThis novel method might be very useful for monitoring of the progression of AD. Geriatr Gerontol Int 2014; 14: 716-723.

引用

页码：716 / 723

页数：8

共 31 条

[11] PET imaging of amyloid deposition in patients with mild cognitive impairment [J].

Forsberg, Anton ;

Engler, Henry ;

Almkvist, Ove ;

Blomquist, Gunnar ;

Hagman, Goran ;

Wall, Anders ;

Ringheim, Anna ;

Langstrom, Bengt ;

Nordberg, Agneta .

NEUROBIOLOGY OF AGING, 2008, 29 (10) :1456-1465

[12] Clinical and pathological correlates of apolipoprotein E epsilon 4 in Alzheimer's disease [J].

GomezIsla, T ;

West, HL ;

Rebeck, GW ;

Harr, SD ;

Growdon, JH ;

Locascio, JJ ;

Perls, TT ;

Lipsitz, LA ;

Hyman, BT .

ANNALS OF NEUROLOGY, 1996, 39 (01) :62-70

[13] Structural modifications of human albumin in diabetes [J].

Guerin-Dubourg, A. ;

Catan, A. ;

Bourdon, E. ;

Rondeau, P. .

DIABETES & METABOLISM, 2012, 38 (02) :171-178

[14] Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease [J].

Henneman, W. J. P. ;

Vrenken, H. ;

Barnes, J. ;

Sluimer, I. C. ;

Verwey, N. A. ;

Blankenstein, M. A. ;

Klein, M. ;

Fox, N. C. ;

Scheltens, P. ;

Barkhof, F. ;

van der Flier, W. M. .

NEUROLOGY, 2009, 73 (12) :935-940

[15] CSF AND SERUM CONCENTRATIONS OF ALBUMIN AND IGG IN ALZHEIMERS-DISEASE [J].

KAY, AD ;

MAY, C ;

PAPADOPOULOS, NM ;

COSTELLO, R ;

ATACK, JR ;

LUXENBERG, JS ;

CUTLER, NR ;

RAPOPORT, SI .

NEUROBIOLOGY OF AGING, 1987, 8 (01) :21-25

[16] Decreased Clearance of CNS β-Amyloid in Alzheimer's Disease [J].

Mawuenyega, Kwasi G. ;

Sigurdson, Wendy ;

Ovod, Vitaliy ;

Munsell, Ling ;

Kasten, Tom ;

Morris, John C. ;

Yarasheski, Kevin E. ;

Bateman, Randall J. .

SCIENCE, 2010, 330 (6012) :1774-1774

[17]

MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939

[18]

Menard S., 2001, APPL LOGISTIC REGRES, Vsecond, P75

[19] 11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration [J].

Rabinovici, G. D. ;

Furst, A. J. ;

O'Neil, J. P. ;

Racine, C. A. ;

Mormino, E. C. ;

Baker, S. L. ;

Chetty, S. ;

Patel, P. ;

Pagliaro, T. A. ;

Klunk, W. E. ;

Mathis, C. A. ;

Rosen, H. J. ;

Miller, B. L. ;

Jagust, W. J. .

NEUROLOGY, 2007, 68 (15) :1205-1212

[20] Cognitive screening and neuropsychological assessment in early Alzheimer's disease [J].

Salmon, DP ;

Lange, KL .

CLINICS IN GERIATRIC MEDICINE, 2001, 17 (02) :229-+

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