Recent Advance of Biological Molecular Imaging Based on Lanthanide-Doped Upconversion-Luminescent Nanomaterials

被引：101

作者：

Min, Yuanzeng ^{[1
]}

Li, Jinming ^{[1
]}

Liu, Fang ^{[1
]}

Padmanabhan, Parasuraman ^{[2
]}

Yeow, Edwin K. L. ^{[1
]}

Xing, Bengang ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

[2] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 637553, Singapore

来源：

NANOMATERIALS | 2014年 / 4卷 / 01期

关键词：

upconversion nanoparticles; molecular imaging; luminescent nanomaterials; BETA-GALACTOSIDASE ACTIVITY; PHASE-CONTROLLED SYNTHESIS; VIVO PHOTODYNAMIC THERAPY; NEAR-INFRARED EMISSION; IN-VIVO; CANCER-THERAPY; UPCONVERTING NANOPHOSPHORS; LIVING SUBJECTS; DRUG-DELIVERY; QUANTUM DOTS;

D O I：

10.3390/nano4010129

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Lanthanide-doped upconversion-luminescent nanoparticles (UCNPs), which can be excited by near-infrared (NIR) laser irradiation to emit multiplex light, have been proven to be very useful for in vitro and in vivo molecular imaging studies. In comparison with the conventionally used down-conversion fluorescence imaging strategies, the NIR light excited luminescence of UCNPs displays high photostability, low cytotoxicity, little background auto-fluorescence, which allows for deep tissue penetration, making them attractive as contrast agents for biomedical imaging applications. In this review, we will mainly focus on the latest development of a new type of lanthanide-doped UCNP material and its main applications for in vitro and in vivo molecular imaging and we will also discuss the challenges and future perspectives.

引用

页码：129 / 154

页数：26

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