Vesicle priming and depriming: A SNAP decision

被引:5
|
作者
Heidelberger, R [1 ]
Matthews, G
机构
[1] Univ Texas, Sch Med, Dept Neurobiol & Anat, Houston, TX 77030 USA
[2] SUNY Stony Brook, Dept Neurobiol & Behav, Stony Brook, NY 11794 USA
关键词
D O I
10.1016/S0896-6273(04)00039-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Synapses have a limited pool of vesicles that are docked and primed for rapid release. In neuroendocrine cells, splice variants of the SNARE protein SNAP-25 and phosphorylation of SNAP-25 independently influence the size of the releasable vesicle pool, possibly by altering the rate of vesicle depriming. Pre- and posttranslational modifications of SNAP-25 may therefore affect synaptic strength.
引用
收藏
页码:311 / 313
页数:3
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