Extract of Rhus verniciflua stokes protects the diet-induced hyperlipidemia in mice

被引：16

作者：

Jeong, Se-Jin ^{[1
,2
]}

Park, Jong-Gil ^{[3
]}

Kim, Sinai ^{[1
,2
]}

Kweon, Hyae Yon ^{[1
,2
]}

Seo, Seungwoon ^{[1
,2
]}

Na, Dae-Seung ^{[4
]}

Lee, Dongho ^{[5
]}

Hong, Cheol Yi ^{[6
]}

Na, Chun-Soo ^{[6
]}

Dong, Mi-Sook ^{[4
]}

Oh, Goo Taeg ^{[1
,2
]}

机构：

[1] Ewha Womans Univ, Dept Life Sci, Natl Creat Initiat, Immune & Vasc Cell Network Res Ctr, Seoul, South Korea

[2] Ewha Womans Univ, Program GT5, Seoul, South Korea

[3] Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY USA

[4] Korea Univ, Sch Life Sci & Biotechnol, Seoul, South Korea

[5] Korea Univ, Coll Life Sci & Biotechnol, Seoul 136713, South Korea

[6] Lifetree Biotech Co Ltd, Lifetree Biotechnol Inst, Gyeonggi Do, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2015年 / 38卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

Rhus verniciflua stokes (RVS); Hyperlipidemia; Bile acid biosynthesis; Liver X receptor alpha (LXR alpha); Cyp7a1; NUCLEAR RECEPTOR LXR; METABOLIC SYNDROME; ETHANOL EXTRACT; CELL-LINES; PATHWAY; ATHEROSCLEROSIS; HYPERCHOLESTEROLEMIA; CYTOTOXICITY; APOPTOSIS; COMPOUND;

D O I：

10.1007/s12272-015-0579-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Rhus verniciflua stokes (RVS) is a popular medicinal plant in oriental medicines which is commonly used to resolve extravasated blood. To elucidate the molecular mechanism of the role of RVS extracts on the regulation of lipid and cholesterol biosynthesis, we investigated whether RVS extract protect the hyperlipidemia in western diet-induced C57BL6/J mice. Mice fed a western diet and additionally RVS extracts was administered orally at a dose of 0.1 or 1 g/kg/day for 2 weeks respectively. Group with higher dose of RVS extract showed a significantly decreased body weight compared with western diet fed mice groups. And total cholesterol, LDL-cholesterol levels and fatty liver formation were also improved especially in group of mice fed western diet supplemented high dose RVS extracts. Next, synthesis of hepatic bile acids were significantly increased in RVS extract fed groups. Furthermore, RVS extracts significantly increase promoter activity of Cyp7a1 via up-regulate the transcriptional expression level of LXR alpha. Our data suggest that RVS extracts could be a potent therapeutic ingredient for prevent a hyperlipidemia via increase of bile acids biosynthesis.

引用

页码：2049 / 2058

页数：10