Dengue Virus Serotypes of Children Diagnosed with Dengue Hemorrhagic Fever at Syarif Hidayatullah and Fatmawati General Hospital Jakarta

Dengue hemorrhagic fever is an infectious disease caused by dengue virus has become one of the most important viral disease worldwide. DHF is re-emerging arboviral disease of great public heath importance, and it has spread to all tropical countries in the world. Pattern of dengue virus are serotypes DEN 1, DEN 2, DEN 3 and DEN 4. Previous studies have suggested that people infected with serotype DEN 3 will experience severe dengue fever, even death. Sequential infection of two serotypes leads to more severe type of disease. The aim was to know pattern of circulation Dengue serotypes at Fatmawati General Hospital and Syarif Hidayatullah Hospital, Jakarta. This study was a descriptive study with cross sectional approach to children diagnosed with DHF and DSS at Syarif Hidayatullah Hospital and Fatmawati General Hospital who hospitalized during May until November 2014. DHF diagnosed was confirmed by WHO 2011 criteria. Blood was taken for virology test by PCR to detect DEN virus. This virology test was done at laboratory of Department of Microbiology, Faculty of Medicine University of Indonesia. Of 30 DHF and DSS patients, we found 21 were positive for serotype DEN 3, six children were positive for serotype DEN 2, and one child was positive for serotype DEN 1, one child was positive for serotype DEN 4. One case was positive with mixed infected serotype that is DEN 1 and DEN 2. Patients who had DSS as many as 2 patients, were infected with mixed DEN 1 and DEN 2, and infected with DEN 3. Conclusion this study serotype DEN 3 mostly infected among DHF patients in Syarif Hidayatullah Hospital and Fatmawati General Hospital Jakarta and among them 2 patients had shock syndromes.