Adenosine and inflammation: what's new on the horizon?

被引：125
作者：
Antonioli, Luca [1 ,2 ,3 ]
Csoka, Balizs [2 ,3 ]
Fornai, Matte [1 ]
Colucci, Rocchina [1 ]
Kokai, Endre [4 ]
Blandizzi, Corrado [1 ]
Hasko, Gyorgy [2 ,3 ,4 ]
机构：
[1] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy
[2] Rutgers State Univ, New Jersey Med Sch, Dept Surg, Newark, NJ 07103 USA
[3] Rutgers State Univ, New Jersey Med Sch, Ctr Immun & Inflammat, Newark, NJ 07103 USA
[4] Univ Debrecen, Med & Hlth Sci Ctr, Dept Med Chem, H-4032 Debrecen, Hungary
来源：
DRUG DISCOVERY TODAY | 2014年 / 19卷 / 08期
基金：
匈牙利科学研究基金会; 美国国家卫生研究院;
关键词：
A(2A) RECEPTOR AGONIST; CENTRAL-NERVOUS-SYSTEM; KINASE INHIBITOR; ALLOSTERIC MODULATION; REGULATING AGENT; TNF-ALPHA; PHARMACOLOGICAL MODULATION; NUCLEOSIDE TRANSPORTER; RHEUMATOID-ARTHRITIS; IMPROVES SURVIVAL;
D O I：
10.1016/j.drudis.2014.02.010
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Adenosine contributes to the maintenance of tissue integrity by modulating the immune system. Encouraging results have emerged with adenosine receptor ligands for the management of several inflammatory conditions in preclinical and clinical settings. However, therapeutic applications of these drugs are sometimes complicated by the occurrence of serious adverse effects. The scientific community is making intensive efforts to design novel adenosine receptor ligands endowed with greater selectivity or to develop innovative compounds acting as allosteric receptor modulators. In parallel, research is focusing on novel pharmacological entities (designated as adenosine-regulating agents) that can increase, in a site- and event-specific manner, adenosine concentrations at the inflammatory site, thereby minimizing the adverse systemic effects of adenosine.
引用
收藏
页码：1051 / 1068
页数：18
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