Connectivity patterns of pallidal DBS electrodes in focal dystonia: A diffusion tensor tractography study

被引：36
作者：
Rozanski, Verena E. [1 ]
Vollmar, Christian [1 ]
Cunha, Joao Paulo [2 ,3 ,4 ]
Neves Tafula, Sergio Miguel [4 ,5 ]
Ahmadi, Seyed-Ahmad [1 ]
Patzig, Maximilian [6 ]
Mehrkens, Jan-Hinnerk [7 ]
Boetzel, Kai [1 ]
机构：
[1] Univ Munich, Dept Neurol, D-81377 Munich, Germany
[2] Univ Porto, INESC TEC Inst Engn Sistemas & Comp Porto, P-4200465 Oporto, Portugal
[3] Univ Porto, Fac Engn, P-4200465 Oporto, Portugal
[4] Portuguese Brain Imaging Res Network, P-3000548 Coimbra, Portugal
[5] Univ Aveiro, IEETA Inst Engn Elect & Telemat Aveiro, P-3810193 Aveiro, Portugal
[6] Univ Munich, Dept Neuroradiol, D-81377 Munich, Germany
[7] Univ Munich, Dept Neurosurg, D-81377 Munich, Germany
来源：
NEUROIMAGE | 2014年 / 84卷
关键词：
Diffusion tensor imaging; Deep brain stimulation; Basal ganglia; Dystonia; Motor networks; DEEP-BRAIN-STIMULATION; GLOBUS-PALLIDUS; CERVICAL DYSTONIA; FIBER TRACKING; MOTOR; ABNORMALITIES; MECHANISMS; LOCATIONS; INTERNUS; CIRCUITS;
D O I：
10.1016/j.neuroimage.2013.09.009
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Deep brain stimulation (DBS) of the internal pallidal segment (GPi: globus pallidus internus) is gold standard treatment for medically intractable dystonia, but detailed knowledge of mechanisms of action is still not available. There is evidence that stimulation of ventral and dorsal GPi produces opposite motor effects. The aim of this study was to analyse connectivity profiles of ventral and dorsal GPi. Probabilistic tractography was initiated from DBS electrode contacts in 8 patients with focal dystonia and connectivity patterns compared. We found a considerable difference in anterior-posterior distribution of fibres along the mesial cortical sensorimotor areas between the ventral and dorsal GPi connectivity. This finding of distinct GPi connectivity profiles further confirms the clinical evidence that the ventral and dorsal GPi belong to different functional and anatomic motor subsystems. Their involvement could play an important role in promoting clinical DBS effects in dystonia. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：435 / 442
页数：8
相关论文
共 47 条
[1]   Sensorimotor integration in movement disorders [J].
Abbruzzese, G ;
Berardelli, A .
MOVEMENT DISORDERS, 2003, 18 (03) :231-240
[2]   FUNCTIONAL ARCHITECTURE OF BASAL GANGLIA CIRCUITS - NEURAL SUBSTRATES OF PARALLEL PROCESSING [J].
ALEXANDER, GE ;
CRUTCHER, MD .
TRENDS IN NEUROSCIENCES, 1990, 13 (07) :266-271
[3]  
Bara-Jimenez W, 2000, ANN NEUROL, V47, P377, DOI 10.1002/1531-8249(200003)47:3<377::AID-ANA16>3.0.CO
[4]  
2-2
[5]   Probabilistic diffusion tractography with multiple fibre orientations: What can we gain? [J].
Behrens, T. E. J. ;
Berg, H. Johansen ;
Jbabdi, S. ;
Rushworth, M. F. S. ;
Woolrich, M. W. .
NEUROIMAGE, 2007, 34 (01) :144-155
[6]   Characterization and propagation of uncertainty in diffusion-weighted MR imaging [J].
Behrens, TEJ ;
Woolrich, MW ;
Jenkinson, M ;
Johansen-Berg, H ;
Nunes, RG ;
Clare, S ;
Matthews, PM ;
Brady, JM ;
Smith, SM .
MAGNETIC RESONANCE IN MEDICINE, 2003, 50 (05) :1077-1088
[7]   A role of diffusion tensor imaging fiber tracking in deep brain stimulation surgery: DBS of the dentato-rubro-thalamic tract (drt) for the treatment of therapy-refractory tremor [J].
Coenen, Volker A. ;
Allert, Niels ;
Maedler, Burkhard .
ACTA NEUROCHIRURGICA, 2011, 153 (08) :1579-1585
[8]  
Delmaire C, 2009, ARCH NEUROL-CHICAGO, V66, P502, DOI 10.1001/archneurol.2009.8
[9]   Task-Free Functional MRI in Cervical Dystonia Reveals Multi-Network Changes That Partially Normalize with Botulinum Toxin [J].
Delnooz, Catherine C. S. y ;
Pasman, Jaco W. ;
Beckmann, Christian F. ;
van de Warrenburg, Bart P. C. .
PLOS ONE, 2013, 8 (05)
[10]   Deep brain stimulation mechanisms: beyond the concept of local functional inhibition [J].
Deniau, Jean-Michel ;
Degos, Bertrand ;
Bosch, Clementine ;
Maurice, Nicolas .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2010, 32 (07) :1080-1091
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