Malignant bowel obstruction in advanced ovarian cancer

被引：13

作者：

Dean, Emma ^{[1
,2
,3
]}

Khoja, Leila ^{[1
,2
,4
]}

Clamp, Andrew ^{[1
,2
,3
]}

Jayson, Gordon C. ^{[1
,2
,3
]}

Goonetilleke, Dilly ^{[1
,2
,3
]}

Conway, Alicia M. ^{[1
,2
]}

Hasan, Jurjees ^{[1
,2
]}

机构：

[1] Christie NHS Fdn Trust, Manchester M20 4BX, Lancs, England

[2] Inst Canc Sci, Manchester M20 4BX, Lancs, England

[3] Univ Manchester, Div Mol & Clin Canc Sci, Manchester M13 9NT, Lancs, England

[4] AstraZeneca Ltd, Early Clin Dev, Melbourn Sci Pk, Melbourn SG8 6HB, Herts, England

来源：

FUTURE ONCOLOGY | 2017年 / 13卷 / 06期

关键词：

bowel obstruction; Manchester Bowel Obstruction Score; ovarian cancer; prognostic score; MANAGEMENT; OUTCOMES;

D O I：

10.2217/fon-2016-0431

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: Malignant bowel obstruction (MBO) in ovarian cancer is poorly understood. Methods: This retrospective cohort study analyzed 129 patients with ovarian cancer and MBO. Results: At presentation, 69 (53%) had platinum-resistant, 37 (29%) platinum-sensitive and 23 (18%) chemotherapy-naive disease. In patients receiving chemotherapy following the MBO episode, median overall survival (OS) was 107 days for chemotherapy-naive patients compared with 83 and 86 for platinum-sensitive or platinum-resistant patients (p = 0.98). OS was inferior for best supportive care (45 days) compared with chemotherapy (152 days) or surgery (124 days; p < 0.001). The Manchester Bowel Obstruction Score using Eastern Cooperative Oncology Group and obstruction level discriminated patients by median OS of 181 days (neither) versus 98 days (one) versus 42 days (both; p < 0.01). Conclusion: The Manchester Bowel Obstruction Score may aide treatment stratification.

引用

页码：513 / 521

页数：9

共 50 条

[41] Malignant Large Bowel Obstruction [J].

Muldoon, Roberta L. .

CLINICS IN COLON AND RECTAL SURGERY, 2021, 34 (04) :251-261

[42] Randomized clinical trial comparing octreotide and scopolamine butylbromide in symptom control of patients with inoperable bowel obstruction due to advanced ovarian cancer [J].

Xingang Peng ;

Peige Wang ;

Shikuan Li ;

Guangyong Zhang ;

Sanyuan Hu .

World Journal of Surgical Oncology, 13

[43] Randomized clinical trial comparing octreotide and scopolamine butylbromide in symptom control of patients with inoperable bowel obstruction due to advanced ovarian cancer [J].

Peng, Xingang ;

Wang, Peige ;

Li, Shikuan ;

Zhang, Guangyong ;

Hu, Sanyuan .

WORLD JOURNAL OF SURGICAL ONCOLOGY, 2015, 13

[44] Outcomes of palliative surgery for bowel obstruction in end of life ovarian cancer care in a tertiary cancer centre [J].

Kennedy, Bernard ;

Sexton, Kate ;

Gleeson, Noreen .

EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 2021, 42 (06) :1112-1115

[45] Malignant Bowel Obstruction: A Review of Current Treatment Strategies [J].

Dolan, Elisabeth A. .

AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE, 2011, 28 (08) :576-582

[46] Malignant bowel obstruction: effectiveness and safety of systemic chemotherapy [J].

Caparica, Rafael ;

Amorim, Larissa ;

Amaral, Paulo ;

Uratani, Lucas ;

Muniz, David ;

Hendlisz, Alain ;

de Azambuja, Evandro ;

Glasberg, Joao ;

Takahashi, Tiago Kenji ;

Filho, Elias Abdo ;

Canellas, Rodrigo ;

Saragiotto, Daniel ;

Sabbaga, Jorge ;

Mak, Milena .

BMJ SUPPORTIVE & PALLIATIVE CARE, 2024, 14 (E2) :e1882-e1888

[47] MANAGEMENT OF BOWEL OBSTRUCTION IN ADVANCED AND TERMINAL CANCER-PATIENTS [J].

RIPAMONTI, C ;

DECONNO, F ;

VENTAFRIDDA, V ;

ROSSI, B ;

BAINES, MJ .

ANNALS OF ONCOLOGY, 1993, 4 (01) :15-21

[48] A scoring system for the prognosis and treatment of malignant bowel obstruction [J].

Henry, Jon C. ;

Pouly, Severin ;

Sullivan, Rachael ;

Sharif, Suhail ;

Klemanski, Dori ;

Abdel-Misih, Sherif ;

Arradaza, Nicole ;

Jaijoura, David ;

Schmidt, Carl ;

Bloomston, Mark .

SURGERY, 2012, 152 (04) :747-757

[49] Octreotide for malignant bowel obstruction: Twenty years after [J].

Mercadante, Sebastiano ;

Porzio, Giampiero .

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2012, 83 (03) :388-392

[50] Palliative surgery of malignant small bowel obstruction after colorectal cancer [J].

Koisser, Karin .

WIENER MEDIZINISCHE WOCHENSCHRIFT, 2019, 169 (15-16) :381-386

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