Malignant bowel obstruction in advanced ovarian cancer

被引：13

作者：

Dean, Emma ^{[1
,2
,3
]}

Khoja, Leila ^{[1
,2
,4
]}

Clamp, Andrew ^{[1
,2
,3
]}

Jayson, Gordon C. ^{[1
,2
,3
]}

Goonetilleke, Dilly ^{[1
,2
,3
]}

Conway, Alicia M. ^{[1
,2
]}

Hasan, Jurjees ^{[1
,2
]}

机构：

[1] Christie NHS Fdn Trust, Manchester M20 4BX, Lancs, England

[2] Inst Canc Sci, Manchester M20 4BX, Lancs, England

[3] Univ Manchester, Div Mol & Clin Canc Sci, Manchester M13 9NT, Lancs, England

[4] AstraZeneca Ltd, Early Clin Dev, Melbourn Sci Pk, Melbourn SG8 6HB, Herts, England

来源：

FUTURE ONCOLOGY | 2017年 / 13卷 / 06期

关键词：

bowel obstruction; Manchester Bowel Obstruction Score; ovarian cancer; prognostic score; MANAGEMENT; OUTCOMES;

D O I：

10.2217/fon-2016-0431

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: Malignant bowel obstruction (MBO) in ovarian cancer is poorly understood. Methods: This retrospective cohort study analyzed 129 patients with ovarian cancer and MBO. Results: At presentation, 69 (53%) had platinum-resistant, 37 (29%) platinum-sensitive and 23 (18%) chemotherapy-naive disease. In patients receiving chemotherapy following the MBO episode, median overall survival (OS) was 107 days for chemotherapy-naive patients compared with 83 and 86 for platinum-sensitive or platinum-resistant patients (p = 0.98). OS was inferior for best supportive care (45 days) compared with chemotherapy (152 days) or surgery (124 days; p < 0.001). The Manchester Bowel Obstruction Score using Eastern Cooperative Oncology Group and obstruction level discriminated patients by median OS of 181 days (neither) versus 98 days (one) versus 42 days (both; p < 0.01). Conclusion: The Manchester Bowel Obstruction Score may aide treatment stratification.

引用

页码：513 / 521

页数：9

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