Malignant bowel obstruction in advanced ovarian cancer

被引：13
|
作者：
Dean, Emma [1 ,2 ,3 ]
Khoja, Leila [1 ,2 ,4 ]
Clamp, Andrew [1 ,2 ,3 ]
Jayson, Gordon C. [1 ,2 ,3 ]
Goonetilleke, Dilly [1 ,2 ,3 ]
Conway, Alicia M. [1 ,2 ]
Hasan, Jurjees [1 ,2 ]
机构：
[1] Christie NHS Fdn Trust, Manchester M20 4BX, Lancs, England
[2] Inst Canc Sci, Manchester M20 4BX, Lancs, England
[3] Univ Manchester, Div Mol & Clin Canc Sci, Manchester M13 9NT, Lancs, England
[4] AstraZeneca Ltd, Early Clin Dev, Melbourn Sci Pk, Melbourn SG8 6HB, Herts, England
来源：
FUTURE ONCOLOGY | 2017年 / 13卷 / 06期
关键词：
bowel obstruction; Manchester Bowel Obstruction Score; ovarian cancer; prognostic score; MANAGEMENT; OUTCOMES;
D O I：
10.2217/fon-2016-0431
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: Malignant bowel obstruction (MBO) in ovarian cancer is poorly understood. Methods: This retrospective cohort study analyzed 129 patients with ovarian cancer and MBO. Results: At presentation, 69 (53%) had platinum-resistant, 37 (29%) platinum-sensitive and 23 (18%) chemotherapy-naive disease. In patients receiving chemotherapy following the MBO episode, median overall survival (OS) was 107 days for chemotherapy-naive patients compared with 83 and 86 for platinum-sensitive or platinum-resistant patients (p = 0.98). OS was inferior for best supportive care (45 days) compared with chemotherapy (152 days) or surgery (124 days; p < 0.001). The Manchester Bowel Obstruction Score using Eastern Cooperative Oncology Group and obstruction level discriminated patients by median OS of 181 days (neither) versus 98 days (one) versus 42 days (both; p < 0.01). Conclusion: The Manchester Bowel Obstruction Score may aide treatment stratification.
引用
收藏
页码：513 / 521
页数：9
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