Nanoparticle-Programmed Self-Destructive Neural Stem Cells for Glioblastoma Targeting and Therapy

被引：66
作者：
Cheng, Yu [1 ]
Morshed, Ramin [1 ]
Cheng, Shih-Hsun [2 ]
Tobias, Alex [1 ]
Auffinger, Brenda [1 ]
Wainwright, Derek A. [1 ]
Zhang, Lingjiao [1 ]
Yunis, Catherine [1 ]
Han, Yu [1 ]
Chen, Chin-Tu [2 ]
Lo, Leu-Wei
Aboody, Karen S. [3 ,4 ]
Ahmed, Atique U. [1 ]
Lesniak, Maciej S. [1 ]
机构：
[1] Univ Chicago, Brain Tumor Ctr, Chicago, IL 60637 USA
[2] Univ Chicago, Dept Radiol, Chicago, IL 60637 USA
[3] City Hope Natl Med Ctr, Dept Neurosci, Duarte, CA 91010 USA
[4] City Hope Natl Med Ctr, Beckman Res Inst, Duarte, CA 91010 USA
来源：
SMALL | 2013年 / 9卷 / 24期
关键词：
drug delivery; neural stem cells; mesoporous silica nanoparticles; glioma; glioblastoma; targeted delivery; doxorubicin; MESOPOROUS SILICA NANOPARTICLES; ONCOLYTIC ADENOVIRUS; CONTROLLED-RELEASE; DELIVERY; BRAIN; PH; TUMORS;
D O I：
10.1002/smll.201301111
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A 3-step glioblastoma-tropic delivery and therapy method using nanoparticle programmed self-destructive neural stem cells (NSCs) is demonstrated in vivo: 1) FDA-approved NSCs for clinical trials are loaded with pH-sensitive MSN-Dox; 2) the nanoparticle conjugates provide a delayed drug-releasing mechanism and allow for NSC migration towards a distant tumor site; 3) NSCs eventually undergo cell death and release impregnated MSN-Dox, which subsequently induces toxicity towards surrounding glioma cells. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：4123 / 4129
页数：7
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