Nanoparticle-Programmed Self-Destructive Neural Stem Cells for Glioblastoma Targeting and Therapy

被引：69

作者：

Cheng, Yu ^{[1
]}

Morshed, Ramin ^{[1
]}

Cheng, Shih-Hsun ^{[2
]}

Tobias, Alex ^{[1
]}

Auffinger, Brenda ^{[1
]}

Wainwright, Derek A. ^{[1
]}

Zhang, Lingjiao ^{[1
]}

Yunis, Catherine ^{[1
]}

Han, Yu ^{[1
]}

Chen, Chin-Tu ^{[2
]}

Lo, Leu-Wei

Aboody, Karen S. ^{[3
,4
]}

Ahmed, Atique U. ^{[1
]}

Lesniak, Maciej S. ^{[1
]}

机构：

[1] Univ Chicago, Brain Tumor Ctr, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Radiol, Chicago, IL 60637 USA

[3] City Hope Natl Med Ctr, Dept Neurosci, Duarte, CA 91010 USA

[4] City Hope Natl Med Ctr, Beckman Res Inst, Duarte, CA 91010 USA

来源：

SMALL | 2013年 / 9卷 / 24期

关键词：

drug delivery; neural stem cells; mesoporous silica nanoparticles; glioma; glioblastoma; targeted delivery; doxorubicin; MESOPOROUS SILICA NANOPARTICLES; ONCOLYTIC ADENOVIRUS; CONTROLLED-RELEASE; DELIVERY; BRAIN; PH; TUMORS;

D O I：

10.1002/smll.201301111

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A 3-step glioblastoma-tropic delivery and therapy method using nanoparticle programmed self-destructive neural stem cells (NSCs) is demonstrated in vivo: 1) FDA-approved NSCs for clinical trials are loaded with pH-sensitive MSN-Dox; 2) the nanoparticle conjugates provide a delayed drug-releasing mechanism and allow for NSC migration towards a distant tumor site; 3) NSCs eventually undergo cell death and release impregnated MSN-Dox, which subsequently induces toxicity towards surrounding glioma cells. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4123 / 4129

页数：7

共 30 条

[1] Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas [J].