Effects of antenatal magnesium sulfate treatment on cerebral blood flow velocities in preterm neonates

被引：13
作者：
Imamoglu, E. Y. [1 ]
Gursoy, T. [1 ]
Karatekin, G. [1 ]
Ovali, F. [1 ]
机构：
[1] Zeynep Kamil Matern & Childrens Training & Res Ho, Neonatal Intens Care Unit Istanbul, Istanbul, Turkey
来源：
JOURNAL OF PERINATOLOGY | 2014年 / 34卷 / 03期
关键词：
doppler; middle cerebral artery; magnesium; prematurity; VISCERAL ARTERIES; HEAD POSITION; DOPPLER; INFANTS; BRAIN; PRESSURE; HEMODYNAMICS; RELAXATION; HEMORRHAGE; PREGNANCY;
D O I：
10.1038/jp.2013.182
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
OBJECTIVE: The objective of this study is to investigate the effects of antenatal magnesium sulfate (MgSO4) on cerebral blood flow (CBF) velocities in preterm neonates. STUDY DESIGN: In this prospective case-control study, we included 53 neonates born between 26 and 34 weeks of gestation. Twenty neonates were exposed to MgSO4 antenatally and 33 were not. Serial daily Doppler flow measurements of middle cerebral artery (MCA) were performed. RESULT: Significantly increased MCA mean velocities were found in the MgSO4 group. A progressive increase in serial Doppler measurements of MCA mean velocity from day 1 to day 5 of life was detected in both groups. CONCLUSION: There is significant increase in MCA mean velocities in preterm neonates receiving antenatal MgSO4. This increment in CBF velocities might explain the protective role of MgSO4 in ischemic events and hypoxic brain damage.
引用
收藏
页码：192 / 196
页数：5
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