Clinicobiochemical aspects of flixotide administration in patients with moderate bronchial asthma

Aim. To compare clinical, device and biochemical aspects of monotherapy with flixotide vs combination of flixotide with serevent inpatients with moderate bronchial asthma (MBA). Material and methods. 18 patients with MBA received flixotide and 18 MBA patients flixotide phis serevent for two weeks of lead-in and eight weeks of basic treatment. A special study was made of neutrophils which were examined for activity of LPO-antioxidants and phospholipid spectrum of membranes. Results. There were similar changes in function of the system LPO-antioxidants and lipid structure in neutrophilic membranes of moderate BA patients of both the groups. Conclusion. Clinicobiochemical efficacy of mean doses of a new topic inhalation glucocorticoid flixotide alone or in combination with prolonged beta2-adrenostimulator serevent is demonstrated. There were positive trends in metabolic processes in neurophilic membrane. Use of flixotide in combination with serevent is clinically preferable.