Effects of Stigmasterol and β-Sitosterol on Nonalcoholic Fatty Liver Disease in a Mouse Model: A Lipidomic Analysis

被引：92

作者：

Feng, Simin ^{[1
,2
,3
]}

Gan, Ling ^{[1
]}

Yang, Chung S. ^{[2
]}

Liu, Anna B. ^{[2
]}

Lu, Wenyun ^{[5
,6
]}

Shao, Ping ^{[1
]}

Dai, Zhuqing ^{[4
]}

Sun, Peilong ^{[1
]}

Luo, Zisheng ^{[3
]}

机构：

[1] Zhejiang Univ Technol, Dept Food Sci & Technol, Hangzhou 310014, Zhejiang, Peoples R China

[2] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Chem Biol, Piscataway, NJ 08854 USA

[3] Zhejiang Univ, Coll Biosyst Engn & Food Sci, Key Lab Agroprod Postharvest Handling, Zhejiang Key Lab Agrifood Proc,Minist Agr, Hangzhou 310058, Zhejiang, Peoples R China

[4] Jiangsu Acad Agr Sci, Inst Agroprod Proc, Nanjing 210014, Jiangsu, Peoples R China

[5] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA

[6] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2018年 / 66卷 / 13期

基金：

美国国家卫生研究院; 中国博士后科学基金;

关键词：

stigmasterol; beta-sitosterol; fatty liver; mice; cholesterol; lipidomics; SACCHARUM-OFFICINARUM L; WESTERN-STYLE DIET; OXIDATIVE STRESS; PLANT STEROLS; HEPATIC INFLAMMATION; LOWERING PROPERTIES; METABOLIC SYNDROME; CHOLESTEROL; MICE; PHYTOSTEROLS;

D O I：

10.1021/acs.jafc.7b06146

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

To study the effects of stigmasterol and beta-sitosterol on high-fat Western diet (HFWD)-induced nonalcoholic fatty liver disease (NAFLD), lipidomic analyses were conducted in liver samples collected after 33 weeks of the treatment. Principal component analysis showed these phytosterols were effective in protecting against HFWD-induced NAFLD. Orthogonal projections to latent structures-discriminate analysis (OPLS-DA) and S-plots showed that triacylglycerols (TGs), phosphatidylcholines, cholesteryl esters, diacylglycerols, and free fatty acids (FFAs) were the major lipid species contributing to these discriminations. The alleviation of NAFLD is mainly associated with decreases in hepatic cholesterol, TGs with polyunsaturated fatty acids, and alterations of free hepatic FFA. In condusion, phytosterols, at a dose comparable to that suggested for humans by the FDA for the reduction of plasma cholesterol levels, are shown to protect against NAFLD in this long-term (33-week) study.

引用

页码：3417 / 3425

页数：9

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