Cp*Co(III)-catalyzed amidation of olefinic and aryl C-H bonds: highly selective synthesis of enamides and pyrimidones

被引：43

作者：

Liu, Yuan ^{[1
]}

Xie, Fang ^{[2
]}

Jia, Ai-Qun ^{[1
]}

Li, Xingwei ^{[2
]}

机构：

[1] Hainan Univ, Dept Pharm, State Key Lab Marine Resource Utilizat South Chin, Key Lab Trop Biol Resources,Minist Educ, Haikou 570228, Hainan, Peoples R China

[2] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 34期

基金：

中国国家自然科学基金;

关键词：

EFFICIENT SYNTHESIS; ACTIVATION; INHIBITORS; ALKYNES; DIOXAZOLONES; QUINAZOLINES; HETEROCYCLES; COBALT(III); DERIVATIVES; CYCLIZATION;

D O I：

10.1039/c8cc01447g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient and selective synthesis of enamides via C-H amidation of N-methoxy acrylamides with dioxazolones is realized under [Cp*Co-III] catalysis. The resulting enamide can further selectively cyclize to form pyrimidones, which can also act as a directing group for a second C-H amidation. All these three classes of products were selectively delivered under controlled conditions.

引用

页码：4345 / 4348

页数：4

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