Circulating mitochondria DNA, a non-invasive cancer diagnostic biomarker candidate

被引：41
作者：
Afrifa, Justice [1 ]
Zhao, Tie [1 ]
Yu, Jingcui [1 ]
机构：
[1] Harbin Med Univ, Affiliated Hosp 2, Sci Res Ctr, Harbin 150081, Heilongjiang, Peoples R China
来源：
MITOCHONDRION | 2019年 / 47卷
关键词：
Mitochondria DNA; Non-invasive biomarker; Cancer; Circulating DNA; EPITHELIAL-MESENCHYMAL TRANSITION; PERIPHERAL-BLOOD LEUKOCYTES; OXYGEN SPECIES ACTIVITY; RENAL-CELL CARCINOMA; COPY NUMBER; LIPID-PEROXIDATION; OXIDATIVE STRESS; SERUM; MUTATIONS; PROGRESSION;
D O I：
10.1016/j.mito.2018.12.003
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The mitochondria are defined by their unique structure and cellular functions which includes energy production, metabolic regulation, apoptosis, calcium homeostasis, cell proliferation, cell motility and transport as well as free radical generation. Recent advances geared towards enhancing the diagnostic and prognostic value of cancer patients have targeted the circulating mitochondria genome due to its specific and unique characteristics. Circulating mitochondria DNA is known to possess short length, relatively simple molecular structure and a high copy number. These coupled with its ability to serve as a liquid biopsy makes it an easily accessible non-invasive biomarker for diagnostics and prognostics of various forms of solid tumors. In this article, we review recent findings on circulating mitochondria DNA content in cancer. In addition, we provide an insight into the potential of circulating mitochondria DNA to act as a non-invasive diagnostic biomarker and its linearity with clinical and sociodemographic characteristics.
引用
收藏
页码：238 / 243
页数：6
相关论文
共 81 条
[1]  
Andreola J. O, 2012, CLIN CHEM LAB MED, V51, P277
[2]   Mitochondrial DNA Content Varies with Pathological Characteristics of Breast Cancer [J].
Bai, Ren-Kui ;
Chang, Julia ;
Yeh, Kun-Tu ;
Lou, Mary Ann ;
Lu, Jyh-Feng ;
Tan, Duan-Jun ;
Liu, Hao ;
Wong, Lee-Jun C. .
JOURNAL OF ONCOLOGY, 2011, 2011
[3]   The fingerprint of phantom mutations in mitochondrial DNA data [J].
Bandelt, HJ ;
Quintana-Murci, L ;
Salas, A ;
Macaulay, V .
AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 71 (05) :1150-1160
[4]   The layered structure of human mitochondrial DNA nucleoids [J].
Bogenhagen, Daniel F. ;
Rousseau, Denis ;
Burke, Stephanie .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (06) :3665-3675
[5]   FOOD-INTAKE AND THE MENSTRUAL-CYCLE - A RETROSPECTIVE ANALYSIS, WITH IMPLICATIONS FOR APPETITE RESEARCH [J].
BUFFENSTEIN, R ;
POPPITT, SD ;
MCDEVITT, RM ;
PRENTICE, AM .
PHYSIOLOGY & BEHAVIOR, 1995, 58 (06) :1067-1077
[6]   A disproportionate role for mtDNA in Dobzhansky-Muller incompatibilities? [J].
Burton, Ronald S. ;
Barreto, Felipe S. .
MOLECULAR ECOLOGY, 2012, 21 (20) :4942-4957
[7]   Cells depleted of mitochondrial DNA (ρ0) yield insight into physiological mechanisms [J].
Chandel, NS ;
Schumacker, PT .
FEBS LETTERS, 1999, 454 (03) :173-176
[8]   Large heterogeneity of mitochondrial DNA transcription and initiation of replication exposed by single-cell imaging [J].
Chatre, Laurent ;
Ricchetti, Miria .
JOURNAL OF CELL SCIENCE, 2013, 126 (04) :914-926
[9]   Elevated Mitochondrial DNA Copy Number in Peripheral Blood and Tissue Predict the Opposite Outcome of Cancer: A Meta-Analysis [J].
Chen, Nan ;
Wen, Shu ;
Sun, Xiaoru ;
Fang, Qian ;
Huang, Lin ;
Liu, Shuai ;
Li, Wanling ;
Qiu, Meng .
SCIENTIFIC REPORTS, 2016, 6
[10]   High leukocyte mitochondrial DNA content contributes to poor prognosis in glioma patients through its immunosuppressive effect [J].
Chen, Y. ;
Zhang, J. ;
Huang, X. ;
Zhang, J. ;
Zhou, X. ;
Hu, J. ;
Li, G. ;
He, S. ;
Xing, J. .
BRITISH JOURNAL OF CANCER, 2015, 113 (01) :99-106
123456789